ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Base Information

Chemical Name:ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
CAS No.:37801-57-3
Molecular Formula:C10H10ClN3O2
Molecular Weight:239.661
Hs Code.:2933990090
DSSTox Substance ID:DTXSID60396653
Nikkaji Number:J922.881K
Wikidata:Q27187978
ChEMBL ID:CHEMBL1726550
Mol file:37801-57-3.mol

Synonyms:ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate;37801-57-3;ethyl 4-chloro-1-methylpyrazolo[3,4-b]pyridine-5-carboxylate;MFCD03012939;Bionet2_001378;Oprea1_588277;MLS000764001;SCHEMBL2626726;CHEMBL1726550;DTXSID60396653;CHEBI:108994;ILWRYGALHSASQT-UHFFFAOYSA-N;HMS1367O14;HMS2711B16;BBL101071;STL554865;AKOS005094529;ETHYL4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE;PB32321;SMR000336141;CS-0053840;EN300-128325;5T-0007;Q27187978;Z1613072046;Ethyl 4-chloro-1-methyl-1H-pyrazolo-[3,4-b]pyridine-5-carboxylate;1-Methyl-4-chloro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester;4-chloro-1-methyl-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester

Suppliers and Price of ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+%
1g
$ 364.00

Chemenu
ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+%
1g
$ 397.00

Chemenu
ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+%
100mg
$ 142.00

Chemenu
ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+%
50mg
$ 93.00

Chemenu
ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+%
250mg
$ 238.00

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 95.00%
5MG
$ 623.82

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 95.00%
10MG
$ 618.50

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 95.00%
1MG
$ 586.97

Alichem
Ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
1g
$ 465.12

Alichem
Ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
250mg
$ 178.36

Total 14 raw suppliers

Chemical Property of ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Chemical Property:

Vapor Pressure:0.000113mmHg at 25°C
Boiling Point:336.3oC at 760 mmHg
PKA:1.43±0.30(Predicted)
Flash Point:157.2oC
PSA：57.01000
Density:1.42g/cm3
LogP:1.79840
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:239.0461543
Heavy Atom Count:16
Complexity:277

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C2C(=C1Cl)C=NN2C

Technology Process of ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

There total 4 articles about ethyl 4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1192-21-8
5-Amino-1-methylpyrazole

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 37801-57-3
4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: 5-Amino-1-methylpyrazole; diethyl 2-ethoxymethylenemalonate; at 110 ℃; for 1.5h;

With trichlorophosphate; at 110 ℃; for 3.5h;
DOI:10.1016/j.bmc.2017.07.052

Reference yield:

: 37799-77-2
diethyl 2-[(1-methyl-1H-pyrazol-5-ylamino)methylene]malonate

: 37801-57-3
4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; at 120 ℃;
DOI:10.1248/cpb.52.1098

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 37801-57-3
4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 120 °C

2: POCl₃ / 120 °C

With trichlorophosphate; 1: Michael addition;
DOI:10.1248/cpb.52.1098