1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI)

Base Information

• Chemical Name: 1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI)
• CAS No.: 18106-97-3
• Molecular Formula: C₇H₇N₇
• Molecular Weight: 189.179
• Hs Code.: 2933990090
• Mol file: 18106-97-3.mol

Synonyms:1,3,5-Triazine-2,4-diamine,6-pyrazinyl- (9CI); s-Triazine, 2,4-diamino-6-(pyrazinyl)- (8CI); ENT 51408;NSC 699729

Chemical Property of 1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI)

Chemical Property:

• Vapor Pressure: 4.7E-13mmHg at 25°C
• Boiling Point: 571.1°Cat760mmHg
• Flash Point: 334°C
• PSA: 117.95000
• Density: 1.508g/cm³
• LogP: -0.64680

Purity/Quality:

99% ^*data from raw suppliers

1,3,5-TRIAZINE-2,4-DIAMINE, 6-(2-PYRAZINYL)- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI), also known as PzTA, is a DNA base-like ligand that forms water-soluble copper(II) complexes with potential chemotherapeutic applications. These complexes exhibit DNA-binding properties through groove interactions, with hydrophobic forces playing a key role in adduct formation. Additionally, the ligand contributes to the complexes' ability to cleave DNA oxidatively, mimic superoxide dismutase (SOD) activity, and display cytotoxicity against human cancer cell lines. The interaction with human serum albumin (HSA) further highlights its relevance in drug delivery and bioactivity.

Technology Process of 1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI)

There total 3 articles about 1,3,5-Triazine-2,4-diamine, 6-(2-pyrazinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrazine carbonitrile (19847-12-2) + N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) → 2,4-diamino-6-(2'-pyrazin)-1,3,5-triazine (18106-97-3)

Guidance literature:

With potassium hydroxide; In 2-methoxy-ethanol; at 170 ℃;

DOI:10.1007/s11243-017-0200-6

Reference yield:

2-pyrazine carbonitrile (19847-12-2) + dicyandiamide (127099-85-8,780722-26-1) → 2,4-diamino-6-(2'-pyrazin)-1,3,5-triazine (18106-97-3)

Guidance literature:

With potassium hydroxide; In 2-methoxy-ethanol; at 170 ℃; for 4h;

DOI:10.1039/c3dt53577k

Reference yield:

→ 2,4-diamino-6-(2'-pyrazin)-1,3,5-triazine (18106-97-3)

Guidance literature:

Cyanpyrazin, Dicyandiamid (KOH);

upstream raw materials:

2-pyrazine carbonitrile

dicyandiamide

N-Cyanoguanidine