4-CHLORO-2-ISOPROPYL-QUINAZOLINE

Base Information

• Chemical Name: 4-CHLORO-2-ISOPROPYL-QUINAZOLINE
• CAS No.: 38154-42-6
• Molecular Formula: C₁₁H₁₁ClN₂
• Molecular Weight: 206.675
• Hs Code.: 2933990090
• Mol file: 38154-42-6.mol

Synonyms:4-Chlor-2-isopropylchinazolin;4-chloro-2-isopropylquinazoline;

Chemical Property of 4-CHLORO-2-ISOPROPYL-QUINAZOLINE

Chemical Property:

• Vapor Pressure: 0.501mmHg at 25°C
• Melting Point: 72-73 °C
• Boiling Point: 198.686oC at 760 mmHg
• PKA: 1.17±0.30(Predicted)
• Flash Point: 92.159oC
• PSA: 25.78000
• Density: 1.201g/cm3
• LogP: 3.40660

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-2-isopropylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-CHLORO-2-ISOPROPYL-QUINAZOLINE

There total 4 articles about 4-CHLORO-2-ISOPROPYL-QUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-Isopropyl-3H-quinazolin-4-one (13182-64-4) → 4-chloro-2-isopropyl-quinazoline (38154-42-6)

Guidance literature:

With diethylamine; trichlorophosphate; In hexane; for 3h; Heating;

DOI:10.1055/s-2001-18080

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 4-chloro-2-isopropyl-quinazoline (38154-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Na; MeOH / cooling

1.2: 47 percent / methanol / 6.5 h / 25 - 80 °C

2.1: 64 percent / N,N-diethylaniline; POCl₃ / benzene / 3 h / Heating

With methanol; sodium; N,N-diethylaniline; trichlorophosphate; In benzene;

DOI:10.1021/jo049195+

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 4-chloro-2-isopropyl-quinazoline (38154-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOMe / ice-cooling

1.2: 47 percent / methanol / 6.5 h / 25 - 80 °C

2.1: 66 percent / POCl₃; Et₂NH / hexane / 3 h / Heating

With sodium methylate; diethylamine; trichlorophosphate; In hexane;

DOI:10.1055/s-2001-18080

upstream raw materials:

2-Isopropyl-3H-quinazolin-4-one

anthranilic acid

Refernces

• 1、 Connolly,Guiry. "A facile and versatile route to 2-substituted-4(3H)-quinazolinones and quinazolines". . p. 1707 - 1710. Retrieved 2007/10/03.