4-PHENYLBENZYLAMINE

Base Information

• Chemical Name: 4-PHENYLBENZYLAMINE
• CAS No.: 712-76-5
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Hs Code.: 29214990
• Mol file: 712-76-5.mol

Synonyms:Benzylamine,p-phenyl- (7CI,8CI);1-(Biphenyl-4-yl)methanamine;4-(Aminomethyl)biphenyl;4-Phenylbenzylamine;Biphenyl-4-ylmethanamine;NSC 402180;[(1,1'-Biphenyl-4-yl)methyl]amine;[(Biphenyl-4-yl)methyl]amine;p-Phenylbenzylamine;

Chemical Property of 4-PHENYLBENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.000235mmHg at 25°C
• Melting Point: 48-53 °C(lit.)
• Boiling Point: 325.1 °C at 760 mmHg
• PKA: 9.05±0.10(Predicted)
• Flash Point: 158 °C
• PSA: 26.02000
• Density: 1.048±0.06 g/cm3(Predicted)
• LogP: 3.51260

Purity/Quality:

99% ^*data from raw suppliers

4-Phenylbenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Phenylbenzylamine may be used in the synthesis of:squaric acid asymmetric diamides of glycopeptide antibioticsasymmetric diamides of daunomycin and carminomycinN-(biphenyl-4-ylmethyl)-1-hydroxy-6-thioxo-1,6-dihydropyridine-2-carboxamide4-Phenylbenzylamine may also be used in the synthesis of Gd3+ chelates of DOTA(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) type ligands.

Technology Process of 4-PHENYLBENZYLAMINE

There total 3 articles about 4-PHENYLBENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-cyano-1,1'-biphenyl (2920-38-9) → 4-Methylbiphenyl (644-08-6) + N-(4-phenyl)benzylamine (712-76-5)

Guidance literature:

With Raney Ni-Al; In potassium hydroxide; water; at 90 ℃; for 25.5h;

DOI:10.1016/S0040-4039(00)00636-5

Reference yield:

4-cyano-1,1'-biphenyl (2920-38-9) → N-(1-biphenylmethylene)-1-biphenemethanamine + N-(4-phenyl)benzylamine (712-76-5)

Guidance literature:

With cobalt; In 1,4-dioxane; at 140 ℃; for 24h; under 37503.8 Torr; Temperature; Reagent/catalyst; Time;

DOI:10.1039/c9cy00225a

Reference yield:

→ N-(4-phenyl)benzylamine (712-76-5) + N-([1,1??a€????′-Biphenyl]-4-ylmethyl)[1,1??a€????′-biphenyl]-4-methanamine (730235-24-2)

Guidance literature:

With hydrogen; nickel; decalin; at 100 ℃;

upstream raw materials:

4-cyano-1,1'-biphenyl

Downstream raw materials:

2-biphenyl-4-yl-5-phenyl-pyridine

N-Biphenyl-4-ylmethyl-4-methoxy-benzenesulfonamide

biphenyl-4-ylmethyl-[2-(3,7-dichloro-1H-indol-4-yloxy)-ethyl]-amine

Refernces

• 1、 Tsukinoki, Takehito,Kanda, Tadashige,Liu, Guo-Bin,Tsuzuki, Hirohisa,Tashiro, Masashi. "Organic reaction in water. Part 3: A facile method for reduction of aromatic rings using a Raney Ni-Al alloy in dilute aqueous alkaline solution under mild conditions". . p. 5865 - 5868. Retrieved 2007/10/03.