2α,3α-Dimethylcyclobutanone

Base Information

• Chemical Name: 2α,3α-Dimethylcyclobutanone
• CAS No.: 38559-13-6
• Molecular Formula: C6H10O
• Molecular Weight: 98.1448
• Mol file: 38559-13-6.mol

Synonyms:2,3-Dimethyl-cyclobutanone;

Chemical Property of 2α,3α-Dimethylcyclobutanone

Chemical Property:

• Vapor Pressure: 9.12mmHg at 25°C
• PSA: 17.07000
• LogP: 1.23140

Purity/Quality:

2,3-Dimethylcyclobutan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2α,3α-Dimethylcyclobutanone

There total 13 articles about 2α,3α-Dimethylcyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-hex-4-yn-2-ol (99206-61-8,19780-83-7) → 4-hexen-3-one (2497-21-4,50396-87-7,50396-96-8,130981-55-4,25659-22-7) + 2,3-dimethylcyclobutan-1-one (38559-13-6)

Guidance literature:

Multistep reaction; (i) 3-nitro-benzenesulfonyl chloride, Py, (ii) CF₃CO₂Na, CF₃CO₂H;

Reference yield:

2,4-dimethyl-1-cyclobutenyl nonaflate (97487-07-5) → (+/-)-hex-4-yn-2-ol (99206-61-8,19780-83-7) + 2,3-dimethylcyclobutan-1-one (38559-13-6) + 5-(2,2,2-trifluoroethoxy)-2-hexyne + 2,3-dimethyl-1-(2,2,2-trifluoroethoxy)cyclobutene

Guidance literature:

With 2,2,2-trifluoroethanol; In water; at 25 ℃; Further byproducts given;

DOI:10.1021/ja00304a034

Reference yield:

2,3-dimethyl-1-cyclobutenyl nonaflate (97487-06-4) → (+/-)-hex-4-yn-2-ol (99206-61-8,19780-83-7) + 2,3-dimethylcyclobutan-1-one (38559-13-6) + 5-(2,2,2-trifluoroethoxy)-2-hexyne + 2,3-dimethyl-1-(2,2,2-trifluoroethoxy)cyclobutene

Guidance literature:

With 2,2,2-trifluoroethanol; In water; at 25 ℃; Further byproducts given;

DOI:10.1021/ja00304a034

upstream raw materials:

(+/-)-hex-4-yn-2-ol

5-(3-nitro-benzenesulfonyloxy)-hex-2-yne

Toluene-4-sulfonic acid 2-methyl-pent-3-ynyl ester

4-hexyn-2-yl p-toluenesulfonate

Refernces