4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester

Base Information

• Chemical Name: 4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester
• CAS No.: 39080-62-1
• Molecular Formula: C11H16N2O3
• Molecular Weight: 224.25600
• DSSTox Substance ID: DTXSID40874242
• Nikkaji Number: J45.352H
• Mol file: 39080-62-1.mol

Synonyms:4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester;39080-62-1;SCHEMBL5184909;DTXSID40874242;4H-PYRIDO[1,2-A]PYRIMIDINE-3-CARBOXYLIC ACID, 1,;3-Carbethoxy-1,1a,6,7,8,9-hexahydro-4H-pyrido[1,2-a]pyrimidin-4-one;3-Carboethoxy-1,1a,6,7,8,9-hexahydro-4H-pyrido[1,2-a]pyrimidin-4-one;1,6,7,8,9,9a-Hexahydro-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester;Ethyl 4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylate #;4-OXO-1,6,7,8,9,9A-HEXAHYDRO-4H-PYRIDO(1,2-A)PYRIMIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property of 4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester

Chemical Property:

• PSA: 58.64000
• LogP: 0.64190
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 224.11609238
• Heavy Atom Count: 16
• Complexity: 338

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CNC2CCCCN2C1=O

Technology Process of 4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester

There total 3 articles about 4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylate (32092-18-5) → 4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (39080-62-1)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/ja01141a079

Reference yield:

3-ethoxy-3-oxo-2-(pyridine-2-yl-aminomethylene)-propanoic acid ethyl ester (39080-52-9) → 4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (39080-62-1)

Guidance literature:

Multi-step reaction with 2 steps

2: platinum; ethanol / Hydrogenation

With ethanol; platinum;

DOI:10.1021/ja01141a079

Reference yield:

→ 4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester (39080-62-1)

Guidance literature:

Heterocyclus (XVIIIa), NaBH4;

upstream raw materials:

ethyl 4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carboxylate

3-ethoxy-3-oxo-2-(pyridine-2-yl-aminomethylene)-propanoic acid ethyl ester