2-Phenyl-2H-1,2,3-triazol-4-amine

Base Information

• Chemical Name: 2-Phenyl-2H-1,2,3-triazol-4-amine
• CAS No.: 39102-26-6
• Molecular Formula: C8H8N4
• Molecular Weight: 160.178
• Mol file: 39102-26-6.mol

Synonyms:4-amino-2-phenyl-1,2,3-triazole;4-amino-2-phenyl-2H-1,2,3-triazole;2-Phenyl-2H-1,2,3-triazol-4-amine;2-phenyl-2H-[1,2,3]triazol-4-ylamine;2-phenyl-1,2,3-triazole-4-ylamine;2-Phenyl-2H-[1,2,3]triazol-4-ylamin;

Chemical Property of 2-Phenyl-2H-1,2,3-triazol-4-amine

Chemical Property:

• PSA: 56.73000
• LogP: 1.43070

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyl-2H-1,2,3-triazol-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Phenyl-2H-1,2,3-triazol-4-amine is used in the preparation of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1''-cyclohexane]-4''-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist

Technology Process of 2-Phenyl-2H-1,2,3-triazol-4-amine

There total 10 articles about 2-Phenyl-2H-1,2,3-triazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-nitro-2-phenyl-2H-1,2,3-triazole (27200-08-4) → 4-amino-2-phenyl-2H-1,2,3-triazole (39102-26-6)

Guidance literature:

With sulfuric acid; iron; In ethanol; for 2h; Heating;

Reference yield: 34.0%

4-nitro-2-phenyl-2H-1,2,3-triazole (27200-08-4) → 4-amino-2-phenyl-2H-1,2,3-triazole (39102-26-6) + 1,2-bis(2-phenyl-2H-1,2,3-triazol-yl)hydrazine

Guidance literature:

With calcium chloride; zinc; In ethanol; Heating;

DOI:10.1023/B:RUJO.0000034977.74026.b3

Reference yield: 7.0%

1-methoxy-2-phenyl-1,2,3-triazolium tetrafluoroborate → 4-amino-2-phenyl-2H-1,2,3-triazole (39102-26-6) + 2-phenyl-2H-1,2,3-triazole 1-oxide (77896-39-0)

Guidance literature:

With ammonia; In acetonitrile; at 20 ℃; for 72h;

DOI:10.1039/P19810000503

upstream raw materials:

2-phenyl-2H-1,2,3-triazole-4-carboxamide

4-nitro-2-phenyl-2H-1,2,3-triazole

2-nitro-2-(phenylhydrazono)acetaldehyde oxime

2-phenyl-2H-1,2,3-triazole 1-oxide

Downstream raw materials:

trans-3-oxo-N-(2-phenyl-2H-1,2,3-triazol-4-yl)-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide