6-hydroxy-1,2-dihydrocyclobuta(a)naphthalene-2-carboxylic acid

Base Information

• Chemical Name: 6-hydroxy-1,2-dihydrocyclobuta(a)naphthalene-2-carboxylic acid
• CAS No.: 125363-72-6
• Molecular Formula: C₁₃H₁₀O₃
• Molecular Weight: 214.221
• Mol file: 125363-72-6.mol

Synonyms:Cyclobuta[a]naphthalene-2-carboxylicacid, 1,2-dihydro-6-hydroxy-, (?à)-

Chemical Property of 6-hydroxy-1,2-dihydrocyclobuta(a)naphthalene-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 8.37E-11mmHg at 25°C
• Boiling Point: 499.7°Cat760mmHg
• Flash Point: 270.1°C
• PSA: 57.53000
• Density: 1.471g/cm³
• LogP: 2.26970

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

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Technology Process of 6-hydroxy-1,2-dihydrocyclobuta(a)naphthalene-2-carboxylic acid

There total 2 articles about 6-hydroxy-1,2-dihydrocyclobuta(a)naphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 6-acetoxy-1,2-dihydrocyclobutanaphthalene-2-carboxylate → 6-hydroxy-1,2-dihydrocyclobutanaphthalene-2-carboxylic acid (125363-72-6)

Guidance literature:

With sodium hydroxide; for 0.5h; Ambient temperature;

DOI:10.1016/0039-128X(89)90064-0

Reference yield:

methyl 6-acetoxy-2a-hydroxy-1,2,2a,8b-tetrahydrocyclobutanaphthalene-2-carboxylate → 6-hydroxy-1,2-dihydrocyclobutanaphthalene-2-carboxylic acid (125363-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / Et₃N, Me-SO₂-Cl / CH₂Cl₂ / ice-salt cooling to r.t.

2: 94 percent / 5percent NaOH / 0.5 h / Ambient temperature

With sodium hydroxide; methanesulfonyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/0039-128X(89)90064-0

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