Technology Process of 3-Azabicyclo[3.1.0]hexane-2-methanol, 3-(phenylmethyl)-, (1S,2S,5R)-
There total 5 articles about 3-Azabicyclo[3.1.0]hexane-2-methanol, 3-(phenylmethyl)-, (1S,2S,5R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / toluene; water / 5 h / Reflux
2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C
2.2: 4 h / 0 °C
2.3: 7.5 h / 0 - 17 °C
3.1: dihydrogen peroxide / ethyl acetate / 0.5 h / 0 °C
3.2: 12 h / 15 °C
4.1: sodium hydride / dimethyl sulfoxide / 1 h / 50 °C
4.2: 2 h / 55 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
With
lithium aluminium tetrahydride; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride; toluene-4-sulfonic acid;
In
tetrahydrofuran; water; dimethyl sulfoxide; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide / ethyl acetate / 0.5 h / 0 °C
1.2: 12 h / 15 °C
2.1: sodium hydride / dimethyl sulfoxide / 1 h / 50 °C
2.2: 2 h / 55 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
With
lithium aluminium tetrahydride; dihydrogen peroxide; sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / dimethyl sulfoxide / 1 h / 50 °C
1.2: 2 h / 55 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux
With
lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide;
