Boceprevir Key interMediate

Base Information

Chemical Name:Boceprevir Key interMediate
CAS No.:394735-37-6
Molecular Formula:C19H32N2O5
Molecular Weight:368.473
Hs Code.:

Synonyms:

Suppliers and Price of Boceprevir Key interMediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 9 raw suppliers

Chemical Property of Boceprevir Key interMediate

Chemical Property:

PSA：95.94000
LogP:2.82220

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of Boceprevir Key interMediate

There total 20 articles about Boceprevir Key interMediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 864801-47-8
[(S)-1-((1R,2S,5S)-2-Hydroxymethyl-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-3-carbonyl)-2,2-dimethyl-propyl]-carbamic acid tert-butyl ester

: 394735-37-6
(1R,2S,5S)-3-((S)-2-tert-butoxycarbonylamino-3,3-dimethylbutyryl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; at 0 ℃; for 3h;
DOI:10.1021/jm060077j

Reference yield: 89.0%

: 394735-26-3
(1R,2S,5S)-3-((S)-2-tert-Butoxycarbonylamino-3,3-dimethyl-butyryl)-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid methyl ester

: 394735-37-6
(1R,2S,5S)-3-((S)-2-tert-butoxycarbonylamino-3,3-dimethylbutyryl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 25 ℃; for 2h; Temperature; Solvent;

Reference yield:

: 134107-65-6
(3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one

: 394735-37-6
(1R,2S,5S)-3-((S)-2-tert-butoxycarbonylamino-3,3-dimethylbutyryl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: BuLi / tetrahydrofuran

1.2: tetrahydrofuran / -78 - 20 °C

2.1: LiAlH₄ / tetrahydrofuran / Heating

3.1: H₂ / Pd/C

4.1: acetone / 3 h / -5 °C

5.1: toluene; methanol

6.1: HCl / dioxane

7.1: BOP; N-methylmorpholine / CH₂Cl₂; dimethylformamide / 24 h / 20 °C

8.1: LiOH*H₂O / tetrahydrofuran; H₂O / 20 °C

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; 4.1: Jones oxidation;
DOI:10.1021/jm060325b