N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide

Base Information

• Chemical Name: N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide
• CAS No.: 41506-62-1
• Molecular Formula: C19H16N2O3
• Molecular Weight: 320.348
• Hs Code.: 2924299090
• European Community (EC) Number: 255-419-3
• UNII: 2Z9GG6AL4B
• DSSTox Substance ID: DTXSID4068323
• Nikkaji Number: J320.093K
• Wikidata: Q72434673
• Mol file: 41506-62-1.mol

Synonyms:41506-62-1;N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide;NAPHTHOL AS-P;N-(4-acetamidophenyl)-3-hydroxynaphthalene-2-carboxamide;2Z9GG6AL4B;EINECS 255-419-3;2-Naphthalenecarboxamide, N-(4-(acetylamino)phenyl)-3-hydroxy-;2-Naphthalenecarboxamide, N-[4-(acetylamino)phenyl]-3-hydroxy-;EC 255-419-3;N-[4-(Acetylamino)phenyl]-3-hydroxy-2-naphthalenecarboxamide;N-(4-(ACETYLAMINO)PHENYL)-3-HYDROXY-2-NAPHTHALENECARBOXAMIDE;UNII-2Z9GG6AL4B;Oprea1_319951;Oprea1_642341;SCHEMBL9291851;DTXSID4068323;AKOS001454743;FT-0622932;W-110954;Z57187387;2-HYDROXY-3-NAPHTHOYLAMINO-4'-ACETYLAMINOBENZENE

Chemical Property of N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide

Chemical Property:

• Vapor Pressure: 1.08E-11mmHg at 25°C
• Refractive Index: 1.744
• Boiling Point: 526.2 °C at 760 mmHg
• Flash Point: 272 °C
• PSA: 78.43000
• Density: 1.369 g/cm ³
• LogP: 3.90210
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 320.11609238
• Heavy Atom Count: 24
• Complexity: 460

Purity/Quality:

99.9% ^*data from raw suppliers

N-(4-ACETYLAMINOPHENYL)-3-HYDROXYNAPHTHALENE-2-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C=C2O

Technology Process of N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide

There total 2 articles about N-(4-Acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetyl-p-phenylenediamine (122-80-5) + 3-Hydroxy-2-naphthoic acid (92-70-6) → N-[4-(acetylamino)phenyl]-3-hydroxy-2-naphthaleneformamide (41506-62-1)

Guidance literature:

With phosphorus trichloride; Multistep reaction; 1) xylene, 80 deg C, 10 min; 2) xylene, reflux, 2 h;

DOI:10.1021/ac00080a022

Reference yield:

→ N-[4-(acetylamino)phenyl]-3-hydroxy-2-naphthaleneformamide (41506-62-1)

Guidance literature:

/BRN= 3379469/;

Reference yield: 100.0%

4-chloro-3-amino-benzoic acid amide (19694-10-1) + N-[4-(acetylamino)phenyl]-3-hydroxy-2-naphthaleneformamide (41506-62-1) → Pigment Orange 38 (12236-64-5)

Guidance literature:

4-chloro-3-amino-benzoic acid amide; With hydrogenchloride; In water; at 30 - 40 ℃; for 1h; Large scale;

With sodium nitrite; In water; at 0 ℃; for 1h; Large scale;

N-[4-(acetylamino)phenyl]-3-hydroxy-2-naphthaleneformamide; With sodium hydroxide; In water; at 70 ℃; Temperature; Large scale;

upstream raw materials:

N-acetyl-p-phenylenediamine

3-Hydroxy-2-naphthoic acid

Downstream raw materials:

Pigment Orange 38

Refernces