3-(acetyloxy)-15-chloro-14-hydroxybufa-20,22-dienolide

Base Information

• Chemical Name: 3-(acetyloxy)-15-chloro-14-hydroxybufa-20,22-dienolide
• CAS No.: 39707-16-9
• Molecular Formula: C₂₆H₃₅ClO₅
• Molecular Weight: 463.014
• Mol file: 39707-16-9.mol

Synonyms:3b-Acetoxy-15a-chloro-14-hydroxy-5b-bufa-20,22-dienolide; NSC 237023

Chemical Property of 3-(acetyloxy)-15-chloro-14-hydroxybufa-20,22-dienolide

Chemical Property:

• Vapor Pressure: 1.45E-16mmHg at 25°C
• Boiling Point: 593.6°Cat760mmHg
• Flash Point: 312.8°C
• Density: 1.26g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(acetyloxy)-15-chloro-14-hydroxybufa-20,22-dienolide

There total 3 articles about 3-(acetyloxy)-15-chloro-14-hydroxybufa-20,22-dienolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

resibufogenin 3-acetate (4029-64-5) → 3β-acetoxy-15α-chloro-14-hydroxy-5β,14β-bufa-20,22-dienolide (39707-16-9)

Guidance literature:

With hydrogenchloride; chloroform;

DOI:10.1002/hlca.19520350733

Reference yield:

acetic anhydride (108-24-7) + 15α-chloro-3β,14-dihydroxy-5β,14β-bufa-20,22-dienolide (39707-12-5) → 3β-acetoxy-15α-chloro-14-hydroxy-5β,14β-bufa-20,22-dienolide (39707-16-9)

Guidance literature:

With pyridine;

DOI:10.1002/hlca.19520350733

Reference yield:

→ 15α-Chlorbufalin-3-acetat (39707-16-9)

Guidance literature:

3d, Ac2O, Pyridin;

DOI:10.1021/jo00952a019

upstream raw materials:

acetic anhydride

15α-chloro-3β,14-dihydroxy-5β,14β-bufa-20,22-dienolide

resibufogenin 3-acetate