[1,1'-Biphenyl]-3-carboxylic acid, 4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio ]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester

Base Information

Chemical Name:[1,1'-Biphenyl]-3-carboxylic acid, 4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio ]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester
CAS No.:396725-49-8
Molecular Formula:C47H54N2O5S
Molecular Weight:759.022
Hs Code.:

[1,1'-Biphenyl]-3-carboxylic acid,
4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio
]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of [1,1'-Biphenyl]-3-carboxylic acid, 4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio ]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester

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Technology Process of [1,1'-Biphenyl]-3-carboxylic acid, 4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio ]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester

There total 8 articles about [1,1'-Biphenyl]-3-carboxylic acid, 4'-[[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(triphenylmethyl)thio ]propyl]amino]-2'-propoxy-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77337-82-7
1-bromo-2-methoxy-4-nitrobenzene

: 396725-49-8
2-propanoxy-4-N-[2-(R)-N-tert-butoxycarbonylamino-3-(triphenylmethyl)thiopropyl]amino-3'-tert-butoxycarbonylbiphenyl

Guidance literature:: Multi-step reaction with 10 steps

1: 83 percent / aq. Pd(OAc)2 / acetone / Heating

2: 75 percent / aq. KMnO₄; pyridine / Heating

3: 88 percent / 48percent aq. HBr; AcOH / 5 h / Heating

4: 98 percent / thionyl chloride / 2 h / Heating

5: 77 percent / K₂CO₃ / acetone / 5 h / Heating

6: 100 percent / aq. NaOH / methanol

7: (COCl)2

8: H₂ / Pd/C

9: 160 mg / NaBCNH₃

With pyridine; palladium diacetate; sodium hydroxide; potassium permanganate; thionyl chloride; oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; acetone;
DOI:10.1021/jm0103099

Reference yield:

: 17933-03-8
m-tolylboronic acid

: 396725-49-8
2-propanoxy-4-N-[2-(R)-N-tert-butoxycarbonylamino-3-(triphenylmethyl)thiopropyl]amino-3'-tert-butoxycarbonylbiphenyl

Guidance literature:: Multi-step reaction with 10 steps

1: 83 percent / aq. Pd(OAc)2 / acetone / Heating

2: 75 percent / aq. KMnO₄; pyridine / Heating

3: 88 percent / 48percent aq. HBr; AcOH / 5 h / Heating

4: 98 percent / thionyl chloride / 2 h / Heating

5: 77 percent / K₂CO₃ / acetone / 5 h / Heating

6: 100 percent / aq. NaOH / methanol

7: (COCl)2

8: H₂ / Pd/C

9: 160 mg / NaBCNH₃

With pyridine; palladium diacetate; sodium hydroxide; potassium permanganate; thionyl chloride; oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; acetone;
DOI:10.1021/jm0103099

Reference yield:

: 191103-12-5
2-methoxy-4-nitro-3'-methylbiphenyl

: 396725-49-8
2-propanoxy-4-N-[2-(R)-N-tert-butoxycarbonylamino-3-(triphenylmethyl)thiopropyl]amino-3'-tert-butoxycarbonylbiphenyl

Guidance literature:: Multi-step reaction with 9 steps

1: 75 percent / aq. KMnO₄; pyridine / Heating

2: 88 percent / 48percent aq. HBr; AcOH / 5 h / Heating

3: 98 percent / thionyl chloride / 2 h / Heating

4: 77 percent / K₂CO₃ / acetone / 5 h / Heating

5: 100 percent / aq. NaOH / methanol

6: (COCl)2

7: H₂ / Pd/C

8: 160 mg / NaBCNH₃

With pyridine; sodium hydroxide; potassium permanganate; thionyl chloride; oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; acetone;
DOI:10.1021/jm0103099