Carbonothioic acid, O-(1,1-dimethylethyl) S-[2-(hydroxymethyl)phenyl] ester

Base Information

• Chemical Name: Carbonothioic acid, O-(1,1-dimethylethyl) S-[2-(hydroxymethyl)phenyl] ester
• CAS No.: 396725-76-1
• Molecular Formula: C12H16O3S
• Molecular Weight: 240.323
• Mol file: 396725-76-1.mol

Synonyms:

Chemical Property of Carbonothioic acid, O-(1,1-dimethylethyl) S-[2-(hydroxymethyl)phenyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonothioic acid, O-(1,1-dimethylethyl) S-[2-(hydroxymethyl)phenyl] ester

There total 3 articles about Carbonothioic acid, O-(1,1-dimethylethyl) S-[2-(hydroxymethyl)phenyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + o-hydroxymethyl thiophenol (4521-31-7) → O-(tert-butyl) S-[2-(hydroxymethyl)phenyl] thiocarbonate (396725-76-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.126

Reference yield:

C15H18O6S → O-(tert-butyl) S-[2-(hydroxymethyl)phenyl] thiocarbonate (396725-76-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm0103099

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → O-(tert-butyl) S-[2-(hydroxymethyl)phenyl] thiocarbonate (396725-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / DMAP; Et₃N / tetrahydrofuran / 20 °C

2: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

3: NaBH₄ / tetrahydrofuran / 1 h / 0 °C

With dmap; sodium tetrahydroborate; triethylamine; In tetrahydrofuran;

DOI:10.1021/jm0103099

upstream raw materials:

di-tert-butyl dicarbonate

o-hydroxymethyl thiophenol

Downstream raw materials:

2-S-(t-butoxycarbonyl)mercaptobenzaldehyde

2-phenyl-4-(2-t-butoxycarbonylmercapto)benzylamino-3'-methoxycarbonylbiphenyl