6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate

Base Information

Chemical Name:6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate
CAS No.:3932-49-8
Molecular Formula:C26H34 F2 O7
Molecular Weight:496.549
Hs Code.:
European Community (EC) Number:223-503-9
DSSTox Substance ID:DTXSID00960039
Nikkaji Number:J217.767F
Wikidata:Q82941048
Mol file:3932-49-8.mol

Synonyms:3932-49-8;EINECS 223-503-9;6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate;C26H34F2O7;C26-H34-F2-O7;SCHEMBL4734156;DTXSID00960039;Pregn-4-ene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-;2-(4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,3,4,4a,4b,5,6,6a,9a,10,10a,10b,11,12-tetradecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate;21-(Acetyloxy)-6alpha,9-difluoro-11beta-hydroxy-16alpha,17-[(1-methylethylidene)bisoxy]pregn-4-ene-3,20-dione

Suppliers and Price of 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate

Chemical Property:

Vapor Pressure:2.15E-16mmHg at 25°C
Boiling Point:590.3°Cat760mmHg
Flash Point:310.8°C
PSA：99.13000
Density:1.32g/cm³
LogP:3.16160
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:496.22725974
Heavy Atom Count:35
Complexity:1030

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)CCC54C)F)F)O)C)OC(O2)(C)C
Isomeric SMILES:CC(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@]4([C@H]3C[C@@H](C5=CC(=O)CC[C@@]54C)F)F)O)C)OC(O2)(C)C

Technology Process of 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate

There total 2 articles about 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 21-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 356-12-7
fluocinonide

: 3932-49-8
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Guidance literature:: With Wilkinson's catalyst; hydrogen; In tetrahydrofuran; toluene;
DOI:10.1002/jlcr.1575

Reference yield:

: 67-73-2
fluocinolone Acetonide

: 3932-49-8
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl trifluoromethanesulfonate / dichloromethane

2: Wilkinson's catalyst; hydrogen / tetrahydrofuran; toluene

With Wilkinson's catalyst; trimethylsilyl trifluoromethanesulfonate; hydrogen; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/jlcr.1762

Reference yield:

: 3932-49-8
21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

: 67-73-2
fluocinolone Acetonide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap

2: benzeneseleninic anhydride / toluene / 7 h / Reflux

3: potassium carbonate / methanol; water

With pyridine; dmap; benzeneseleninic anhydride; potassium carbonate; In methanol; water; toluene;
DOI:10.1002/jlcr.1762