Aziridine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)-

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Chemical Name:Aziridine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)-
CAS No.:397306-14-8
Molecular Formula:C₂₃H₃₉NO₅SSi
Molecular Weight:469.718
Hs Code.:

Aziridine,
2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon
yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)-

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Chemical Property of Aziridine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)-

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Technology Process of Aziridine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)-

There total 3 articles about Aziridine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-3-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]-, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92844-99-0
(2E)-5-<(2-tetrahydropyranyl)oxy>pent-2-en-1-ol

: 397306-14-8
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: L-(+)-DIPT; Ti(O-i-Pr)4; TBHP / CH₂Cl₂ / 20 °C

2.1: NaN₃; MeO(CH₂)2OH / H₂O / Heating

2.2: imidazole / CH₂Cl₂ / 0 °C

2.3: PPh₃ / toluene / Heating

3.1: pyridine / -20 °C

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium azide; L-(+)-diisopropyl tartrate; 2-methoxy-ethanol; In dichloromethane; water; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1055/s-2001-17441

Reference yield:

: 214412-57-4
(2R,3S)-3-[2-((R,S)-tetrahydropyran-2-yloxy)ethyl]oxiran-2-ylmethanol

: 397306-14-8
(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaN₃; MeO(CH₂)2OH / H₂O / Heating

1.2: imidazole / CH₂Cl₂ / 0 °C

1.3: PPh₃ / toluene / Heating

2.1: pyridine / -20 °C

With pyridine; sodium azide; 2-methoxy-ethanol; In water;
DOI:10.1055/s-2001-17441