Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-[(1E)-3-oxo-1-propenyl]-3-[2-(phenylmeth oxy)ethyl]-, (2R,3R)-

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Chemical Name:Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-[(1E)-3-oxo-1-propenyl]-3-[2-(phenylmeth oxy)ethyl]-, (2R,3R)-
CAS No.:397306-49-9
Molecular Formula:C₂₁H₂₃NO₄S
Molecular Weight:385.484
Hs Code.:

Synonyms:

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Chemical Property of Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-[(1E)-3-oxo-1-propenyl]-3-[2-(phenylmeth oxy)ethyl]-, (2R,3R)-

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Technology Process of Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-[(1E)-3-oxo-1-propenyl]-3-[2-(phenylmeth oxy)ethyl]-, (2R,3R)-

There total 6 articles about Aziridine, 1-[(4-methylphenyl)sulfonyl]-2-[(1E)-3-oxo-1-propenyl]-3-[2-(phenylmeth oxy)ethyl]-, (2R,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89923-31-9
(E)-5-(benzyloxy)pent-2-en-1-ol

: 397306-49-9
(E)-3-[(2R,3R)-3-(2-Benzyloxy-ethyl)-1-(toluene-4-sulfonyl)-aziridin-2-yl]-propenal

Guidance literature:: Multi-step reaction with 6 steps

1.1: L-(+)-DIPT; Ti(O-i-Pr)4; TBHP / CH₂Cl₂ / 20 °C

2.1: NaN₃; MeO(CH₂)2OH / H₂O / Heating

2.2: imidazole / CH₂Cl₂ / 0 °C

2.3: PPh₃ / toluene / Heating

3.1: pyridine / -20 °C

4.1: TBAF / acetic acid / 0 °C

5.1: SO₃*Py; Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

6.1: benzene / 20 °C

With pyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium azide; pyridine-SO₃ complex; L-(+)-diisopropyl tartrate; 2-methoxy-ethanol; tetrabutyl ammonium fluoride; triethylamine; In dichloromethane; water; acetic acid; dimethyl sulfoxide; benzene; 1.1: Sharpless asymmetric epoxidation;
DOI:10.1055/s-2001-17441

Reference yield:

: 111466-55-8
((2S,3S)-3-(2-(benzyloxy)ethyl)oxiran-2-yl)methanol

: 397306-49-9
(E)-3-[(2R,3R)-3-(2-Benzyloxy-ethyl)-1-(toluene-4-sulfonyl)-aziridin-2-yl]-propenal

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaN₃; MeO(CH₂)2OH / H₂O / Heating

1.2: imidazole / CH₂Cl₂ / 0 °C

1.3: PPh₃ / toluene / Heating

2.1: pyridine / -20 °C

3.1: TBAF / acetic acid / 0 °C

4.1: SO₃*Py; Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

5.1: benzene / 20 °C

With pyridine; sodium azide; pyridine-SO₃ complex; 2-methoxy-ethanol; tetrabutyl ammonium fluoride; triethylamine; In dichloromethane; water; acetic acid; dimethyl sulfoxide; benzene;
DOI:10.1055/s-2001-17441

Reference yield:

: 397305-87-2
(2R,3S)-2-(2-Benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxymethyl)-aziridine

: 397306-49-9
(E)-3-[(2R,3R)-3-(2-Benzyloxy-ethyl)-1-(toluene-4-sulfonyl)-aziridin-2-yl]-propenal

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / -20 °C

2: TBAF / acetic acid / 0 °C

3: SO₃*Py; Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

4: benzene / 20 °C

With pyridine; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; triethylamine; In dichloromethane; acetic acid; dimethyl sulfoxide; benzene;
DOI:10.1055/s-2001-17441