3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-
CAS No.:397883-98-6
Molecular Formula:C28H36N2O8S
Molecular Weight:560.668
Hs Code.:

3-Oxazolidinecarboxylic acid,
2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb
onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-

Synonyms:

Suppliers and Price of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)-

There total 6 articles about 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-5-[2-oxo-3-(phenylsulfonyl)propyl]-4-[[[(phenylmethoxy)carb onyl]amino]methyl]-, 1,1-dimethylethyl ester, (4R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 116511-95-6
(benzenesulfonyl)methyllithium

: 397883-97-5
(3aR,7aS)-2,2-dimethyl-6-oxo-perhydrooxazolo[4,5-c]pyridine-3,5-dicarboxylic acid-5-benzyl ester-3-tert-butyl ester

: 397883-91-9
(3aR,7aS)-2,2-dimethyl-6-oxo-perhydrooxazolo[4,5-c]pyridine-3-carboxylic acid tert-butyl ester

: 397883-98-6
(4R,5S)-5-(3-benzenesulfonyl-2-oxopropyl)-4-(benzyloxycarbonylaminomethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at -76 ℃; for 0.75h;
DOI:10.1021/ol010221p

Reference yield:

: 366450-24-0
(4S,5R)-4-hydroxy-5-hydroxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 397883-98-6
(4R,5S)-5-(3-benzenesulfonyl-2-oxopropyl)-4-(benzyloxycarbonylaminomethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / pyridine / 0.42 h / -5 - 0 °C

2.1: 90 percent / NaN₃ / dimethylformamide / 22 h / 45 °C

3.1: H₂ / Pd/C / methanol / 44 h

3.2: 100 percent / methanol / 24 h / 65 °C

4.1: 95 percent / TsOH / acetone / 40 h / 20 °C

5.1: nBuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

5.2: 75 percent / tetrahydrofuran; hexane / 0.42 h / -78 °C

6.1: 41 percent / tetrahydrofuran / 0.75 h / -76 °C

With n-butyllithium; sodium azide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol010221p

Reference yield:

: 366450-25-1
(4S,5R)-4-hydroxy-5-methanesulfonyloxymethyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

: 397883-98-6
(4R,5S)-5-(3-benzenesulfonyl-2-oxopropyl)-4-(benzyloxycarbonylaminomethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / NaN₃ / dimethylformamide / 22 h / 45 °C

2.1: H₂ / Pd/C / methanol / 44 h

2.2: 100 percent / methanol / 24 h / 65 °C

3.1: 95 percent / TsOH / acetone / 40 h / 20 °C

4.1: nBuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C

4.2: 75 percent / tetrahydrofuran; hexane / 0.42 h / -78 °C

5.1: 41 percent / tetrahydrofuran / 0.75 h / -76 °C

With n-butyllithium; sodium azide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol010221p