Technology Process of Propanoic acid, 2,2-dimethyl-,
2-[(2S,4R,6S)-2-(4-methoxyphenyl)-6-(2-propynyl)-1,3-dioxan-4-yl]ethyl
ester
There total 13 articles about Propanoic acid, 2,2-dimethyl-,
2-[(2S,4R,6S)-2-(4-methoxyphenyl)-6-(2-propynyl)-1,3-dioxan-4-yl]ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.1021/jo049084a
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: NaH / dimethylformamide / 0.5 h / 0 - 20 °C
1.2: 100 percent / dimethylformamide / 20 °C
2.1: 92 percent / acetic acid; water / tetrahydrofuran / 8 h / 50 - 60 °C
3.1: 91 percent / pyridine / CH2Cl2 / 0 - 20 °C
4.1: 97 percent / DMAP; pyridine / CH2Cl2 / 0 - 20 °C
5.1: 89 percent / K2CO3 / methanol / 20 °C
6.1: ozone / ethyl acetate / 0.12 h / -78 °C
7.1: NaBH4 / methanol / 0.5 h / 0 °C
8.1: 980 mg / pyridine / CH2Cl2 / 5 h / 20 °C
9.1: BF3*Et2O / tetrahydrofuran / 1 h / -78 °C
10.1: (n-Bu)4NF / tetrahydrofuran / 1 h / 0 °C
11.1: 85 percent / DDQ; 4 Angstroem molecular sieves / CH2Cl2 / 3 h / 20 °C
With
pyridine; dmap; sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; ozone; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo049084a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ozone / ethyl acetate / 0.12 h / -78 °C
2: NaBH4 / methanol / 0.5 h / 0 °C
3: 980 mg / pyridine / CH2Cl2 / 5 h / 20 °C
4: BF3*Et2O / tetrahydrofuran / 1 h / -78 °C
5: (n-Bu)4NF / tetrahydrofuran / 1 h / 0 °C
6: 85 percent / DDQ; 4 Angstroem molecular sieves / CH2Cl2 / 3 h / 20 °C
With
pyridine; sodium tetrahydroborate; 4 A molecular sieve; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; ozone; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo049084a
