1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester

Base Information

Chemical Name:1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester
CAS No.:397887-04-6
Molecular Formula:C36H50N2O9Si
Molecular Weight:682.886
Hs Code.:

1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid,
5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-
4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo-
3-phenyl-, methyl ester

Synonyms:

Suppliers and Price of 1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester

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Chemical Property of 1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester

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Technology Process of 1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester

There total 6 articles about 1-Oxa-5-azaspiro[5.5]undec-2-ene-2-carboxylic acid, 5-[(2R)-2-[(2R,3S)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]- 4-oxo-1-[2-oxo-2-(2-propenyloxy)ethyl]-2-azetidinyl]-1-oxopropyl]-4-oxo- 3-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40630-84-0
allyl bromoacetate

: 397886-97-4
5-((R)-2-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionyl)-4-oxo-3-phenyl-1-oxa-5-aza-spiro[5.5]undec-2-ene-2-carboxylic acid methyl ester

: 397887-04-6
5-((R)-2-{(2R,3S)-1-Allyloxycarbonylmethyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionyl)-4-oxo-3-phenyl-1-oxa-5-aza-spiro[5.5]undec-2-ene-2-carboxylic acid methyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1055/s-2001-18778

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 397887-04-6
5-((R)-2-{(2R,3S)-1-Allyloxycarbonylmethyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionyl)-4-oxo-3-phenyl-1-oxa-5-aza-spiro[5.5]undec-2-ene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Ac₂O; H₂SO₄ / acetic acid

2: 92 percent / pyridine / tetrahydrofuran

3: 80 percent / Zn / tetrahydrofuran / Heating

4: 90 percent / NaHMDS / tetrahydrofuran

With pyridine; sulfuric acid; sodium hexamethyldisilazane; acetic anhydride; zinc; In tetrahydrofuran; acetic acid; 3: Reformatsky-type reaction;
DOI:10.1055/s-2001-18778

Reference yield:

: 140-29-4
phenylacetonitrile

: 397887-04-6
5-((R)-2-{(2R,3S)-1-Allyloxycarbonylmethyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-propionyl)-4-oxo-3-phenyl-1-oxa-5-aza-spiro[5.5]undec-2-ene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / NaOMe / methanol

2: 80 percent / Ac₂O; H₂SO₄ / acetic acid

3: 92 percent / pyridine / tetrahydrofuran

4: 80 percent / Zn / tetrahydrofuran / Heating

5: 90 percent / NaHMDS / tetrahydrofuran

With pyridine; sulfuric acid; sodium methylate; sodium hexamethyldisilazane; acetic anhydride; zinc; In tetrahydrofuran; methanol; acetic acid; 4: Reformatsky-type reaction;
DOI:10.1055/s-2001-18778