Technology Process of 2,7-Diazaspiro[4.5]decane-10-acetic acid,
3-ethenyl-2-(5-hexenyl)-7-[(4-methoxyphenyl)methyl]-1,6-dioxo-,
1,1-dimethylethyl ester, (3R,5R,10S)-
There total 12 articles about 2,7-Diazaspiro[4.5]decane-10-acetic acid,
3-ethenyl-2-(5-hexenyl)-7-[(4-methoxyphenyl)methyl]-1,6-dioxo-,
1,1-dimethylethyl ester, (3R,5R,10S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3R, 5S, 10R)-10-(tert-butoxycarbonylmethyl)-7-(4-methoxybenzyl)-3-vinyl-1,6-dioxa-2,7-diaza-spiro[4,5]decane;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
6-iodohex-1-ene;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C
1.2: 95 percent / tetrahydrofuran / -78 °C
2.1: 73 percent / AgOTf; (iPr)2NEt / acetonitrile / 14 h / 20 °C
3.1: (iPr)2NEt / acetonitrile / 16 h / Heating
3.2: 80 percent / H2 / 10 percent Pd/C / methanol / 16 h / 760 Torr
4.1: 99 percent / Mg(ClO4) / acetonitrile / 2 h / 50 °C
5.1: 82 percent / LiBH4 / tetrahydrofuran / 0.58 h / -20 - 20 °C
6.1: 78 percent / Dess-Martin periodinane; H2O / CH2Cl2 / 1 h / 20 °C
7.1: Zn; Ti(OiPr)4 / tetrahydrofuran / 1 h / 20 °C
7.2: 84 percent / tetrahydrofuran / 14 h / 20 °C
8.1: NaH / dimethylformamide / 1 h / 20 °C
8.2: 88 percent / dimethylformamide / 1 h / 20 °C
With
titanium(IV) isopropylate; lithium borohydride; magnesium(II) perchlorate; water; silver trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; zinc;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
7.1: Takai-Nozaki olefination;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 86 percent / DMAP; NEt3 / CH2Cl2 / 72 h / 20 °C
2.1: nBuLi / diethyl ether; hexane / 0.5 h / -78 °C
2.2: 96 percent / diethyl ether; hexane / 1.25 h / -78 - 20 °C
3.1: 73 percent / pTsOH*H2O / 2-methyl-propan-2-ol; diethyl ether / 16 h / 20 °C
4.1: 73 percent / AgOTf; (iPr)2NEt / acetonitrile / 14 h / 20 °C
5.1: (iPr)2NEt / acetonitrile / 16 h / Heating
5.2: 80 percent / H2 / 10 percent Pd/C / methanol / 16 h / 760 Torr
6.1: 99 percent / Mg(ClO4) / acetonitrile / 2 h / 50 °C
7.1: 82 percent / LiBH4 / tetrahydrofuran / 0.58 h / -20 - 20 °C
8.1: 78 percent / Dess-Martin periodinane; H2O / CH2Cl2 / 1 h / 20 °C
9.1: Zn; Ti(OiPr)4 / tetrahydrofuran / 1 h / 20 °C
9.2: 84 percent / tetrahydrofuran / 14 h / 20 °C
10.1: NaH / dimethylformamide / 1 h / 20 °C
10.2: 88 percent / dimethylformamide / 1 h / 20 °C
With
titanium(IV) isopropylate; dmap; lithium borohydride; n-butyllithium; magnesium(II) perchlorate; water; silver trifluoromethanesulfonate; sodium hydride; Dess-Martin periodane; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
9.1: Takai-Nozaki olefination;
DOI:10.1002/1521-3765(20011119)7:22<4811::AID-CHEM4811>3.0.CO;2-P
