22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3

Base Information

Chemical Name:22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3
CAS No.:133910-11-9
Molecular Formula:C31H44 O3
Molecular Weight:464.68
Hs Code.:
Mol file:133910-11-9.mol

Synonyms:1,3-Cyclohexanediol,4-methylene-5-[[octahydro-1-[2-[3-(1-hydroxy-1-methylethyl)phenyl]-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-,[1R-[1a(R*),3ab,4E(1R*,3S*,5Z),7aa]]-

Suppliers and Price of 22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3

Chemical Property:

Vapor Pressure:3.1E-16mmHg at 25°C
Boiling Point:620.1°Cat760mmHg
PKA:14.43±0.40(Predicted)
Flash Point:258.3°C
PSA：60.69000
Density:1.11g/cm³
LogP:6.23360

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3

There total 9 articles about 22-(3-(dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14452-30-3
3'-iodoacetophenone

: 133910-11-9
22-(3-(Dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran; diethyl ether / 1 h / 0 °C

2: CH₂Cl₂ / 12 h / 20 °C

4: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 8 h, 2.) THF, hexane, RT, 12 h

6: 93 percent / Pd(PPh₃)2(OAc)2, CuI, diethylamine / dimethylformamide / 2 h / Ambient temperature

7: H₂, quinoline / Lindlar's catalyst / 1.) EtOAc, hexane, RT, 1 h, 2.) isooctane, reflux, 2 h

8: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With quinoline; copper(l) iodide; dipyridinium dichromate; bis(triphenylphosphine) palladium (Il) acetate; tetrabutyl ammonium fluoride; hydrogen; pyridinium trifluroacetate; diethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a021

Reference yield:

: 102879-20-9
2-(3-iodophenyl)propan-2-ol

: 133910-11-9
22-(3-(Dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂ / 12 h / 20 °C

3: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 8 h, 2.) THF, hexane, RT, 12 h

5: 93 percent / Pd(PPh₃)2(OAc)2, CuI, diethylamine / dimethylformamide / 2 h / Ambient temperature

6: H₂, quinoline / Lindlar's catalyst / 1.) EtOAc, hexane, RT, 1 h, 2.) isooctane, reflux, 2 h

7: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With quinoline; copper(l) iodide; dipyridinium dichromate; bis(triphenylphosphine) palladium (Il) acetate; tetrabutyl ammonium fluoride; hydrogen; pyridinium trifluroacetate; diethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a021

Reference yield:

: 133910-13-1
3-<1'-methyl-1'-(trimethylsilyloxy)ethyl>iodobenzene

: 133910-11-9
22-(3-(Dimethylhydroxymethyl)phenyl)-23,24,25,26,27-pentanor-1-hydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 6 steps

2: 50 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 10 h / Ambient temperature

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 8 h, 2.) THF, hexane, RT, 12 h

4: 93 percent / Pd(PPh₃)2(OAc)2, CuI, diethylamine / dimethylformamide / 2 h / Ambient temperature

5: H₂, quinoline / Lindlar's catalyst / 1.) EtOAc, hexane, RT, 1 h, 2.) isooctane, reflux, 2 h

6: tetrabutylammonium fluoride / tetrahydrofuran / 12 h / Ambient temperature

With quinoline; copper(l) iodide; dipyridinium dichromate; bis(triphenylphosphine) palladium (Il) acetate; tetrabutyl ammonium fluoride; hydrogen; pyridinium trifluroacetate; diethylamine; lithium diisopropyl amide; Lindlar's catalyst; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a021