SAR-ARG-VAL-TYR-ILE-HIS-PRO-ILE

Base Information

• Chemical Name: SAR-ARG-VAL-TYR-ILE-HIS-PRO-ILE
• CAS No.: 37827-06-8
• Molecular Formula: C46H73 N13 O10
• Molecular Weight: 968.167
• Mol file: 37827-06-8.mol

Synonyms:AngiotensinII, 1-(N-methylglycine)-5-L-isoleucine-8-L-isoleucine-; Angiotensin IIIinhibitor (human), N2-(N-methylglycyl)- (9CI); Sarilesin;[Sar1-Ile5-Ile8]-angiotensin II; [Sarcosyl1-Ile5-Ile8]-angiotensin II

Chemical Property of SAR-ARG-VAL-TYR-ILE-HIS-PRO-ILE

Chemical Property:

• PKA: 3.72±0.22(Predicted)
• PSA: 355.05000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 2.98090
• Storage Temp.: -15°C

Purity/Quality:

98% ^*data from raw suppliers

Angiotensin II [Sar1, Ile8] ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SAR-ARG-VAL-TYR-ILE-HIS-PRO-ILE

There total 3 articles about SAR-ARG-VAL-TYR-ILE-HIS-PRO-ILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) + Boc-Tyr-OH (3978-80-1) + (S)-2-tert-Butoxycarbonylamino-3-(3H-imidazol-4-yl)-propionic acid (17791-52-5) → 1,Ile8>angiotensin II (37827-06-8)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm00156a035

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + t-Boc-L-valine (13734-41-3) + N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) + Boc-His(Tos)-OH (35899-43-5) → 1,Ile8>angiotensin II (37827-06-8)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm00114a012

Reference yield:

t-Boc-L-valine (13734-41-3) + N-(tert-butoxycarbonyl)sarcosine (13734-36-6) + t-butyloxycarbonyl-L-arginine (13726-76-6,78603-12-0) + Boc-Tyr-OH (3978-80-1) → sarilesin (37827-06-8)

Guidance literature:

Multistep reaction; solid-phase method;

DOI:10.1021/jm00122a030

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

t-Boc-L-valine

N-(tert-butyloxycarbonyl)-L-isoleucine

Boc-His(Tos)-OH

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