2-CHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-CHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ACID
• CAS No.: 399017-39-1
• Molecular Formula: C11H8ClNO2
• Molecular Weight: 221.643
• Mol file: 399017-39-1.mol

Synonyms:2-Chloro-8-methyl-quinoline-3-carboxylic acid;

Chemical Property of 2-CHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ACID

Chemical Property:

• Boiling Point: 377.3±37.0 °C(Predicted)
• PKA: 2.12±0.30(Predicted)
• PSA: 50.19000
• Density: 1.406±0.06 g/cm3(Predicted)
• LogP: 2.89480

Purity/Quality:

99.0% ^*data from raw suppliers

2-chloro-8-methylquinoline-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-CHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ACID

There total 1 articles about 2-CHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-8-methyl-quinoline-3-carbaldehyde (73568-26-0) → 2-chloro-8-methylquinoline-3-carboxylic acid (399017-39-1)

Guidance literature:

With sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 3h;

DOI:10.1002/jhet.5570380524

Reference yield: 72.0%

5-p-hydroxyphenyl-4H-1,2,4-triazole-3-thiol (3414-96-8) + 2-chloro-8-methylquinoline-3-carboxylic acid (399017-39-1) → C19H12N4O2S (1211543-09-7)

Guidance literature:

With sodium acetate; acetic anhydride; at 120 - 125 ℃; for 6h;

DOI:10.1080/10426500802561450

Reference yield: 70.0%

p-cresol (106-44-5) + 2-chloro-8-methylquinoline-3-carboxylic acid (399017-39-1) → C18H15NO3

Guidance literature:

With potassium carbonate; copper(II) sulfate; N,N-dimethyl-formamide; for 8h; Microwave irradiation;

upstream raw materials:

2-chloro-8-methyl-quinoline-3-carbaldehyde

Downstream raw materials:

C₁₉H₁₂N₄OS

C₁₉H₁₁ClN₄OS

C₁₉H₁₂N₄O₂S

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