N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide

Base Information

Chemical Name:N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide
CAS No.:399043-50-6
Molecular Formula:C15H14FNO2S
Molecular Weight:291.346
Hs Code.:
DSSTox Substance ID:DTXSID701206416

Synonyms:DTXSID701206416;N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide;399043-50-6

Suppliers and Price of N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:291.07292802
Heavy Atom Count:20
Complexity:390

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(SC(=C1C(=O)C2=CC(=CC=C2)F)NC(=O)C)C

Technology Process of N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide

There total 3 articles about N-[3-(3-Fluorobenzoyl)-4,5-dimethyl-2-thienyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66587-69-7
(4,5-dimethyl-2-thienyl)(methyl)methanone

: 399043-50-6
N-[3-(3-fluoro-benzoyl)-4,5-dimethyl-thiophen-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / hydroxylamine hydrochloride; barium carbonate / ethanol / 8 h / Heating

2: 32 percent / PCl₅ / diethyl ether / 0.75 h / 0 - 20 °C

3: tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating

With phosphorus pentachloride; hydroxylamine hydrochloride; tin(IV) chloride; barium carbonate; In diethyl ether; ethanol; 1,2-dichloro-ethane; 3: Friedel-Crafts acylation;
DOI:10.1021/jm010081p

Reference yield:

: 515860-74-9
1-(4,5-dimethyl-2-thiophen-2-yl)-ethanone oxime

: 399043-50-6
N-[3-(3-fluoro-benzoyl)-4,5-dimethyl-thiophen-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / PCl₅ / diethyl ether / 0.75 h / 0 - 20 °C

2: tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating

With phosphorus pentachloride; tin(IV) chloride; In diethyl ether; 1,2-dichloro-ethane; 2: Friedel-Crafts acylation;
DOI:10.1021/jm010081p