2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydro-

Base Information

• Chemical Name: 2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydro-
• CAS No.: 40026-24-2
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Hs Code.: 2932999099
• Mol file: 40026-24-2.mol

Synonyms:6-Chloro-chroman-2-carboxylic acid;2H-1-BENZOPYRAN-2-CARBOXYLIC ACID,6-CHLORO-3,4-DIHYDRO;6-Chlorchroman-2-carbonsaeure;6-CHLORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID;6-CHLOROCHROMANE-2-CARBOXYLIC ACID;

Chemical Property of 2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydro-

Chemical Property:

• PSA: 46.53000
• LogP: 2.11820
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

6-CHLORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydro-

There total 6 articles about 2H-1-Benzopyran-2-carboxylic acid, 6-chloro-3,4-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

6-chloro-4-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (52011-76-4) → (+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid (40026-24-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; for 2h; Heating;

DOI:10.1016/0957-4166(95)00111-2

Reference yield:

(+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid methyl ester (357396-06-6) → (+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid (40026-24-2)

Guidance literature:

With lipase from Candida cylindracea; sodium chloride; calcium chloride; In water; at 37 ℃; for 24h;

DOI:10.1016/S0957-4166(01)00119-7

Reference yield:

C12H13ClO5 → (+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid (40026-24-2)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 0 °C

3: trifluoroacetic acid; triethylsilane / 6 h / 55 °C

4: lithium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

With triethylsilane; aluminum (III) chloride; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; 2: |Mitsunobu Displacement;

DOI:10.1016/j.tetasy.2015.07.006

upstream raw materials:

6-chloro-4-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

(+/-)-6-chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid methyl ester

Refernces

• 1、 -. "Fused bicyclic carboxamide derivatives and methods of their use". Page/Page column 36. . Retrieved 2010/02/11.
• 2、 Loiodice, Fulvio,Longo, Antonio,Bianco, Pasquale,Tortorella, Vincenzo. "6-Chloro-2,3-Dihydro-4H-1-Benzopyran Carboxylic Acids: Synthesis, Optical Resolution and Absolute Configuration". . p. 1001 - 1012. Retrieved 2007/10/03.