Technology Process of 1,2-Pyrrolidinedicarboxylic acid,
5-oxo-4-[[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1-(1,1-dimethylethyl)
2-ethyl ester, (2R,4S)-
There total 4 articles about 1,2-Pyrrolidinedicarboxylic acid,
5-oxo-4-[[4-[(phenylsulfonyl)amino]phenyl]methyl]-, 1-(1,1-dimethylethyl)
2-ethyl ester, (2R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / 2 h / -78 °C
2.1: 100 percent / ammonium formate / 10 percent Pd/C / ethanol / 2 h / Heating
3.1: Et3N; DMAP / CH2Cl2 / 0.75 h / 20 °C
With
dmap; ammonium formate; triethylamine; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm020901d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / 2 h / -78 °C
2.1: 100 percent / ammonium formate / 10 percent Pd/C / ethanol / 2 h / Heating
3.1: Et3N; DMAP / CH2Cl2 / 0.75 h / 20 °C
With
dmap; ammonium formate; triethylamine; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm020901d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / ammonium formate / 10 percent Pd/C / ethanol / 2 h / Heating
2: Et3N; DMAP / CH2Cl2 / 0.75 h / 20 °C
With
dmap; ammonium formate; triethylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane;
DOI:10.1021/jm020901d