5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1-[3-[4-(2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl] propyl]-1,4,6,7-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1-[3-[4-(2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl] propyl]-1,4,6,7-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester
• CAS No.: 400801-21-0
• Molecular Formula: C34H41F3N6O3
• Molecular Weight: 638.733

Synonyms:

Chemical Property of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1-[3-[4-(2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl] propyl]-1,4,6,7-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

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Technology Process of 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1-[3-[4-(2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl] propyl]-1,4,6,7-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester

There total 1 articles about 5H-Pyrazolo[4,3-c]pyridine-5-carboxylic acid, 1-[3-[4-(2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl] propyl]-1,4,6,7-tetrahydro-3-[4-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3-Oxo-propyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (400801-20-9) + 1,3-dihydro-1-methyl-3-(4-piperidinyl)-2H-benzimidazol-2-one (53786-10-0) → 1-{3-[4-(3-Methyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-propyl}-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (400801-21-0)

Guidance literature:

With NaBH(OAc)3; glacial AcOH; sodium hydrogencarbonate; In dichloromethane;

Reference yield: 96.0%

1-{3-[4-(3-Methyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-propyl}-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (400801-21-0) → 1-methyl-3-(1-{3-[3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one (400801-22-1)

Guidance literature:

In dichloromethane; trifluoroacetic acid;

upstream raw materials:

1-(3-Oxo-propyl)-3-(4-trifluoromethyl-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

1,3-dihydro-1-methyl-3-(4-piperidinyl)-2H-benzimidazol-2-one

Downstream raw materials:

1-methyl-3-(1-{3-[3-(4-trifluoromethyl-phenyl)-4,5,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-1-yl]-propyl}-piperidin-4-yl)-1,3-dihydro-benzoimidazol-2-one

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