L-Histidine, N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]- b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Histidine, N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]- b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester
CAS No.:400861-15-6
Molecular Formula:C46H52N6O7S2
Molecular Weight:865.087
Hs Code.:

L-Histidine,
N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]-
b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Histidine, N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]- b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of L-Histidine, N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]- b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester

There total 8 articles about L-Histidine, N-[[1-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]-3-piperidinyl]carbonyl]- b-alanyl-1-[(triphenylmethyl)thio]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32324-19-9
2-methylbenzenesulfonyl isocyanate

: 400861-15-6
2-(3-{[1-(toluene-2-sulfonylaminocarbonyl)-piperidine-3-carbonyl]-amino}-propionylamino)-3-(1-tritylsulfanyl-1H-imidazol-4-yl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 4 °C

2: diisopropyl-carbodiimide; 1-hydroxybenzotriazole / acetonitrile / 4 °C

With benzotriazol-1-ol; diisopropyl-carbodiimide; In acetonitrile;
DOI:10.1021/jm010958k

Reference yield:

: 400859-11-2
N-1-tritylsulfenyl-L-histidine tert-butyl ester

: 400860-16-4
3-{[1-(toluene-2-sulfonylaminocarbonyl)-piperidine-3-carbonyl]-amino}-propionic acid

: 400861-15-6
2-(3-{[1-(toluene-2-sulfonylaminocarbonyl)-piperidine-3-carbonyl]-amino}-propionylamino)-3-(1-tritylsulfanyl-1H-imidazol-4-yl)-propionic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; diisopropyl-carbodiimide; In acetonitrile; at 4 ℃;
DOI:10.1021/jm010958k

Reference yield:

: 71-00-1
L-histidine

: 400861-15-6
2-(3-{[1-(toluene-2-sulfonylaminocarbonyl)-piperidine-3-carbonyl]-amino}-propionylamino)-3-(1-tritylsulfanyl-1H-imidazol-4-yl)-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / Heating

2: Et₃N / acetonitrile / 3 h / 20 °C

3: SOCl₂ / benzene / 3 h / Heating

4: acetonitrile / 2 h / 20 °C

5: hydrazinium hydroxide / ethanol / 5 h / 20 °C

6: diisopropyl-carbodiimide; 1-hydroxybenzotriazole / acetonitrile / 4 °C

With thionyl chloride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; diisopropyl-carbodiimide; In ethanol; toluene; acetonitrile; benzene;
DOI:10.1021/jm010958k