5'-Deoxy-4',5-difluorouridine

Base Information

Chemical Name:5'-Deoxy-4',5-difluorouridine
CAS No.:113548-97-3
Deprecated CAS:1289377-03-2,1613228-18-4
Molecular Formula:C9H10 F2 N2 O5
Molecular Weight:264.186
Hs Code.:
Mol file:113548-97-3.mol

Synonyms:4'-F-5'-dFUrd;5'deoxy-4',5-difluorouridine

Suppliers and Price of 5'-Deoxy-4',5-difluorouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5'DEOXY-4',5-DIFLUOROURIDINE 95.00%
5MG
$ 498.32

Total 2 raw suppliers

Chemical Property of 5'-Deoxy-4',5-difluorouridine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：104.81000
Density:1.69g/cm³
LogP:-0.97570
XLogP3:-1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:1
Exact Mass:264.05577775
Heavy Atom Count:18
Complexity:443

Purity/Quality:

97% ^*data from raw suppliers

5'DEOXY-4',5-DIFLUOROURIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O)F
Isomeric SMILES:C[C@@]1([C@H]([C@H]([C@@H](O1)N2C=C(C(=O)NC2=O)F)O)O)F

Technology Process of 5'-Deoxy-4',5-difluorouridine

There total 5 articles about 5'-Deoxy-4',5-difluorouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 113548-96-2
5'-deoxy-4',5-difluoro-2',3'-bis(benzyloxy)uridine

: 113548-97-3
5'-deoxy-4',5-difluorouridine

Guidance literature:: With hydrogen; palladium dihydroxide; In 1,4-dioxane; for 10h; under 2327.2 Torr;
DOI:10.1021/jm00401a008

Reference yield:

: 113548-95-1
1-(5-deoxy-2,3-bis(benzyloxy)-β-D-erythro-pent-4-enofuranosyl)-5-fluorouracil

: 113548-97-3
5'-deoxy-4',5-difluorouridine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / pyridinium poly(hydrogen fluoride) / tetrahydrofuran / 1 h / -50 °C

2: 31 percent / H₂ / Pd(OH)2/C / dioxane / 10 h / 2327.2 Torr

With hydrogen; pyridine hydrogenfluoride; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00401a008

Reference yield:

: 113548-93-9
2',3'-bis(benzyloxy)-5-fluorouridine

: 113548-97-3
5'-deoxy-4',5-difluorouridine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 0.67 h / 0 °C

2: 67 percent / t-BuOK / dioxane / Ambient temperature

3: 86 percent / pyridinium poly(hydrogen fluoride) / tetrahydrofuran / 1 h / -50 °C

4: 31 percent / H₂ / Pd(OH)2/C / dioxane / 10 h / 2327.2 Torr

With potassium tert-butylate; hydrogen; pyridine hydrogenfluoride; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; pyridine;
DOI:10.1021/jm00401a008