Thiophene, 2,5-dihydro-4-methyl-2-(2-phenylethyl)-, 1,1-dioxide

Base Information

• Chemical Name: Thiophene, 2,5-dihydro-4-methyl-2-(2-phenylethyl)-, 1,1-dioxide
• CAS No.: 401479-44-5
• Molecular Formula: C13H16O2S
• Molecular Weight: 236.335
• Mol file: 401479-44-5.mol

Synonyms:

Chemical Property of Thiophene, 2,5-dihydro-4-methyl-2-(2-phenylethyl)-, 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophene, 2,5-dihydro-4-methyl-2-(2-phenylethyl)-, 1,1-dioxide

There total 4 articles about Thiophene, 2,5-dihydro-4-methyl-2-(2-phenylethyl)-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[3-(2-methyl-prop-2-ene-1-sulfonyl)-pent-4-enyl]-benzene (401479-37-6) → 4-methyl-2-phenethyl-2,5-dihydro-thiophene 1,1-dioxide (401479-44-5)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 18h; Heating;

DOI:10.1021/ol017142y

Reference yield:

5-phenylpent-1-en-3-ol (37904-38-4) → 4-methyl-2-phenethyl-2,5-dihydro-thiophene 1,1-dioxide (401479-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C

2: potassium hydroxide / methanol / 20 °C

3: m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

4: 98 percent / (1,3-di(2-mesityl)imidazolidin-2-yl)(Cy₃P)(Cl)2Ru(=CHPh) / CH₂Cl₂ / 18 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium hydroxide; di-isopropyl azodicarboxylate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 1: Mitsunobu reaction;

DOI:10.1021/ol017142y

Reference yield:

thioacetic acid S-(1-phenethyl-allyl) ester (401479-49-0) → 4-methyl-2-phenethyl-2,5-dihydro-thiophene 1,1-dioxide (401479-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 20 °C

2: m-chloroperbenzoic acid / CH₂Cl₂ / 0 °C

3: 98 percent / (1,3-di(2-mesityl)imidazolidin-2-yl)(Cy₃P)(Cl)2Ru(=CHPh) / CH₂Cl₂ / 18 h / Heating

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; potassium hydroxide; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/ol017142y

upstream raw materials:

[3-(2-methyl-prop-2-ene-1-sulfonyl)-pent-4-enyl]-benzene

5-phenylpent-1-en-3-ol

thioacetic acid S-(1-phenethyl-allyl) ester