1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-
CAS No.:401495-76-9
Molecular Formula:C35H45NO6Si
Molecular Weight:603.831
Hs Code.:

1-Piperidinecarboxylic acid,
6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy)
methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)-

There total 1 articles about 1-Piperidinecarboxylic acid, 6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-2-oxo-3-[(phenylmethoxy) methoxy]-, 1,1-dimethylethyl ester, (3S,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3587-60-8
Benzyloxymethyl chloride

: (6R)-N-tert-butoxycarbonyl-6-[(tert-butyldiphenylsilyl)oxymethyl]-3-hydroxypiperidin-2-one

: 401495-76-9
3-benzyloxymethoxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/b103901f

Reference yield: 57.0%

: 401495-76-9
3-benzyloxymethoxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

: 401495-77-0
(3S,6R)-3-benzyloxymethoxy-6-[(tert-butyldiphenylsilyl)oxymethyl]piperidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.133333h;
DOI:10.1039/b103901f

Reference yield:

: 401495-76-9
3-benzyloxymethoxy-6-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

: Benzoic acid (3R,6R)-6-(tert-butoxycarbonylamino-methyl)-1-methoxycarbonylmethyl-2-oxo-piperidin-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

1: trifluoroacetic acid / dichloromethane / 0.13 h / 0 °C

2: sodium hydride / tetrahydrofuran / 20 °C

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 3 h / 50 °C

4: triethylamine / dichloromethane / 0.75 h / 0 °C

5: sodium azide / N,N-dimethyl-formamide / 80 °C

6: hydrogen / 10percent Pd/C / ethyl acetate / 1.5 h / 20 °C

7: hydrogen / 10percent Pd(OH)2/C / methanol / 20 °C

8: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C

With sodium azide; hydrogen; sodium hydride; triethylamine tris(hydrogen fluoride); triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; 10percent Pd/C; 10percent Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 8: Mitsunobu reaction;
DOI:10.1039/b103901f