Pretomaymycin

Base Information

Chemical Name:Pretomaymycin
CAS No.:81422-30-2
Molecular Formula:C₁₅H₁₆N₂O₃
Molecular Weight:272.304
Hs Code.:

Synonyms:

Suppliers and Price of Pretomaymycin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pretomaymycin

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pretomaymycin

There total 20 articles about Pretomaymycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 615-43-0
2-iodophenylamine

: 81422-30-2,28797-41-3
(E)-pretomaymycin

Guidance literature:: Multi-step reaction with 11 steps

2: 92 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

3: 95 percent / NaH / tetrahydrofuran / -30 °C

4: 87 percent / NH₃ / methanol

5: 69 percent / n-Bu₃N, / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

6: 67 percent / HCl / methanol / 20 h / 50 °C

7: molecular sieve, PCC / CH₂Cl₂ / 2 h / Ambient temperature

8: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h

10: KOH / methanol

11: 1.) LiAlH₄; 2.) silica gel / 1.) THF, -60 degC, 30 min; 2.) AcOEt

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; molecular sieve; tributyl-amine; potassium tert-butylate; ammonia; silica gel; sodium hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)87534-7

Reference yield:

: 108555-56-2
2-iodo-N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)aniline

: 81422-30-2,28797-41-3
(E)-pretomaymycin

Guidance literature:: Multi-step reaction with 7 steps

1: 69 percent / n-Bu₃N, / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

2: 67 percent / HCl / methanol / 20 h / 50 °C

3: molecular sieve, PCC / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h

6: KOH / methanol

7: 1.) LiAlH₄; 2.) silica gel / 1.) THF, -60 degC, 30 min; 2.) AcOEt

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; molecular sieve; tributyl-amine; potassium tert-butylate; silica gel; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)87534-7

Reference yield:

: 108555-53-9
2-iodo-N-(4-hydroxy-1-trifluoroacetyl-1-prolyl)aniline

: 81422-30-2,28797-41-3
(E)-pretomaymycin

Guidance literature:: Multi-step reaction with 10 steps

1: 92 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

2: 95 percent / NaH / tetrahydrofuran / -30 °C

3: 87 percent / NH₃ / methanol

4: 69 percent / n-Bu₃N, / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

5: 67 percent / HCl / methanol / 20 h / 50 °C

6: molecular sieve, PCC / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h

9: KOH / methanol

10: 1.) LiAlH₄; 2.) silica gel / 1.) THF, -60 degC, 30 min; 2.) AcOEt

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; molecular sieve; tributyl-amine; potassium tert-butylate; ammonia; silica gel; sodium hydride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)87534-7