1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE

Base Information

• Chemical Name: 1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE
• CAS No.: 4022-89-3
• Molecular Formula: C6H10N4O
• Molecular Weight: 154.172
• Mol file: 4022-89-3.mol

Synonyms:1-Methyl-5-methylamino-1H-imidazole-4-carboxylic acid amide;1-Methyl-5-methylaminoimidazol-4-carboxamid;4-Carbamoyl-1-methyl-5-methylamino-imidazol;1-methyl-5-(methylamino)imidazole-4-carboxamide;1-methyl-5-(methylamino)-imidazole-4-carboxamide;

Chemical Property of 1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE

Chemical Property:

• Melting Point: 207 - 210 °C
• PSA: 72.94000
• LogP: 0.33400

Purity/Quality:

95% ^*data from raw suppliers

1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE

There total 1 articles about 1-METHYL-5-(METHYLAMINO)-1H-IMIDAZOLE-4-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

3,9-dimethylguanine monohydrate → 3,9-dimethylxanthine (15837-08-8) + 1-Methyl-5-(methylamino)-1H-imidazole-4-carboxamide (4022-89-3) + 1-methyl-5-(1-methyl-ureido)-1H-imidazole-4-carboxylic acid amide (69265-22-1)

Guidance literature:

With potassium hydroxide; In water; for 0.5h; Heating;

DOI:10.1016/0040-4020(82)80248-2

Reference yield: 4.5%

benzyl chloroformate (501-53-1,94274-21-2) + 1-Methyl-5-(methylamino)-1H-imidazole-4-carboxamide (4022-89-3) → 5-<(benzyloxycarbonyl)methylamino>-1-methylimidazole-4-carboxamide (125072-30-2) + (5-Benzyloxycarbonylaminocarbonyl-3-methyl-3H-imidazol-4-yl)-methyl-carbamic acid benzyl ester (124770-90-7) + C30H28N4O7 (124770-89-4)

Guidance literature:

With sodium hydrogencarbonate; In water; for 1.5h; Ambient temperature;

Reference yield:

1-Methyl-5-(methylamino)-1H-imidazole-4-carboxamide (4022-89-3) → 3,9-dimethylxanthine (15837-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / H₂O / Ambient temperature; pH 5, acetate buffer

2: 83 percent / 1 N NaOH / Ambient temperature

With sodium hydroxide; In water;

Downstream raw materials:

5-<(benzyloxycarbonyl)methylamino>-1-methylimidazole-4-carboxamide

(5-Benzyloxycarbonylaminocarbonyl-3-methyl-3H-imidazol-4-yl)-methyl-carbamic acid benzyl ester

C₃₀H₂₈N₄O₇

3,9-dimethylxanthine