Efletirizine

Base Information

• Chemical Name: Efletirizine
• CAS No.: 150756-35-7
• Molecular Formula: C₂₁H₂₄F₂N₂O₃
• Molecular Weight: 390.43
• Mol file: 150756-35-7.mol

Synonyms:Aceticacid, [2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]- (9CI); 2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]aceticacid; Efletirizine;[2-[4-[Bis(p-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid

Chemical Property of Efletirizine

Chemical Property:

• Vapor Pressure: 1.56E-11mmHg at 25°C
• Boiling Point: 517.5°Cat760mmHg
• Flash Point: 266.7°C
• PSA: 53.01000
• Density: 1.256g/cm³
• LogP: 2.64880

Purity/Quality:

97% ^*data from raw suppliers

2-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethoxy]acetic acid HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Efletirizine

There total 3 articles about Efletirizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

→ 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-acetic acid (150756-35-7)

Guidance literature:

Reference yield:

aqueous sodium hydroxyde + 2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxyacetamide dihydrochloride → 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-acetic acid (150756-35-7)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In ethanol; water;

Reference yield:

2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxyacetamide dihydrochloride → 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]-acetic acid (150756-35-7)

Guidance literature:

2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxyacetamide dihydrochloride; With sodium hydroxide; In ethanol; water; for 1.5h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=5;

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