IndoMethacin DiaMide

Base Information

• Chemical Name: IndoMethacin DiaMide
• CAS No.: 402849-25-6
• Molecular Formula: C33H27Cl2N3O5
• Molecular Weight: 616.49100
• Mol file: 402849-25-6.mol

Synonyms:

Chemical Property of IndoMethacin DiaMide

Chemical Property:

• Melting Point: >180°C
• PSA: 89.87000
• LogP: 7.27380
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

IndomethacinDiamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Indomethacin Diamide is an impurity of Indomethacin (I641000), an non-steroidal anti-inflammatory drug commonly used in the treatment of fever, pain and swelling.

Technology Process of IndoMethacin DiaMide

There total 1 articles about IndoMethacin DiaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

N1-(4-Chlorbenzoyl)-N1-(4-methoxyphenyl)hydrazin-hydrochlorid (13815-62-8) + [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → 4-chlorobenzoic acid N'-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-yl]-acetyl}-N-(4-methoxyphenyl)-hydrazide (402849-25-6)

Guidance literature:

N¹-(4-Chlorbenzoyl)-N¹-(4-methoxyphenyl)hydrazin-hydrochlorid; With pyridine; In tetrahydrofuran; at 20 ℃; for 1h;

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid; With dmap; 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 8h; Heating;

DOI:10.1016/S0928-0987(01)00198-1

upstream raw materials:

N¹-(4-Chlorbenzoyl)-N¹-(4-methoxyphenyl)hydrazin-hydrochlorid

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid