3-Quinolinecarboxylic acid, 1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-( 4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-( 4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester
CAS No.:402923-45-9
Molecular Formula:C42H39FN3O7P
Molecular Weight:747.76
Hs Code.:

3-Quinolinecarboxylic acid,
1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-(
4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Quinolinecarboxylic acid, 1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-( 4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-( 4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester

There total 10 articles about 3-Quinolinecarboxylic acid, 1-[4-[[bis(phenylmethoxy)phosphinyl]oxy]phenyl]-6-fluoro-1,4-dihydro-7-( 4-methyl-1-piperazinyl)-4-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 538-37-4
dibenzyl phosphochloridate

: 402923-44-8
6-fluoro-1-(4-hydroxy-phenyl)-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

: 402923-45-9
1-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm0497895

Reference yield:

: 109-01-3
1-methyl-piperazine

: 402923-45-9
1-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 0.67 h / 130 °C

2: DMAP; DCC / CH₂Cl₂ / 2 h / 50 °C

3: aq. HCl / CH₂Cl₂ / 0.5 h / 0 °C

4: NaH / dimethylformamide / 3 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium hydride; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0497895

Reference yield:

: 876-30-2
4-methoxymethyloxyaniline

: 402923-45-9
1-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-6-fluoro-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂ / 0.5 h / 20 °C

2: NaH / 1,2-dimethoxy-ethane / 2 h / 80 °C

3: NaOH / ethanol / 3 h / Heating

4: dimethylsulfoxide / 0.67 h / 130 °C

5: DMAP; DCC / CH₂Cl₂ / 2 h / 50 °C

6: aq. HCl / CH₂Cl₂ / 0.5 h / 0 °C

7: NaH / dimethylformamide / 3 h / 0 - 20 °C

With hydrogenchloride; dmap; sodium hydroxide; sodium hydride; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0497895