2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride

Base Information

• Chemical Name: 2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride
• CAS No.: 108736-91-0
• Molecular Formula: C19H27 N O . Cl H
• Molecular Weight: 321.8847
• DSSTox Substance ID: DTXSID30910860
• Mol file: 108736-91-0.mol

Synonyms:2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride;108736-91-0;2-Methylamino-2-(2'-hydroxy-2'-phenylethyl)tricyclo(3.3.1.1(sup 3,7))decane hydrochloride;Tricyclo(3.3.1.1(sup 3,7))decane-2-ethanol, 2-(methylamino)-alpha-phenyl-, hydrochloride;DTXSID30910860;LS-157106;2-[2-(Methylamino)adamantan-2-yl]-1-phenylethan-1-ol--hydrogen chloride (1/1)

Chemical Property of 2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride

Chemical Property:

• Vapor Pressure: 8.19E-08mmHg at 25°C
• Boiling Point: 420.2°Cat760mmHg
• Flash Point: 102.3°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 321.1859422
• Heavy Atom Count: 22
• Complexity: 346

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1(C2CC3CC(C2)CC1C3)CC(C4=CC=CC=C4)O.Cl

Technology Process of 2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride

There total 3 articles about 2-(Methylamino)-alpha-phenyltricyclo(3.3.1.1(sup 3,7))decane-2-ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-5-phenyl-spiro3,7>decane> hydrochloride (108737-02-6) → 2-methylamino-2-(2'-hydroxy-2'-phenyl)ethyltricyclo<3.3.1.13,7>decane hydrochloride (108736-91-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; Ambient temperature;

DOI:10.1016/0223-5234(88)90144-4

Reference yield:

2-Adamantanone (700-58-3) → 2-methylamino-2-(2'-hydroxy-2'-phenyl)ethyltricyclo<3.3.1.13,7>decane hydrochloride (108736-91-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium bicarbonate / ethanol / 3 h / Heating

2: toluene / Heating

3: H₂ / 5percent Pd-C / acetic acid / Ambient temperature

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; acetic acid; toluene;

DOI:10.1016/0223-5234(88)90144-4

Reference yield:

α,α-adamantylidene-N-methyl nitrone (57777-70-5) → 2-methylamino-2-(2'-hydroxy-2'-phenyl)ethyltricyclo<3.3.1.13,7>decane hydrochloride (108736-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: H₂ / 5percent Pd-C / acetic acid / Ambient temperature

With hydrogen; palladium on activated charcoal; In acetic acid; toluene;

DOI:10.1016/0223-5234(88)90144-4

upstream raw materials:

2-methyl-5-phenyl-spiro3,7>decane> hydrochloride

2-Adamantanone

α,α-adamantylidene-N-methyl nitrone