tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate

Base Information

• Chemical Name: tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate
• CAS No.: 403860-48-0
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.325
• European Community (EC) Number: 832-983-4
• DSSTox Substance ID: DTXSID70461669
• Wikidata: Q82286053
• Mol file: 403860-48-0.mol

Synonyms:403860-48-0;tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate;(R,R)-1-N-Boc-Amino-2-aminoindane;tert-butyl N-[(1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl]carbamate;(1R,2R)-2-Amino-1-(Boc-amino)indane;tert-Butyl [(1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl]carbamate;MFCD12068381;SCHEMBL5729415;DTXSID70461669;TQR0478;XAJYUOBKHFIVFN-VXGBXAGGSA-N;AKOS026670840;AS-35063;CS-0139683;EN300-717501;A923769;(1R,2R)-2-Amino-1-(Boc-amino)indane, AldrichCPR;Trans-2-Amino-1-[(1,1-dimethylethoxy)carbonylamino]indan;(1R, 2R)-2-amino-1-[(1,1-dimethylethoxy)carbonylamino]indan;(R,R)-(2-Amino-indan-1-yl)-carbamic acid tert-butyl ester;trans-2-amino-1-{N-[(1,1-dimethylethoxy)]carbonylamino}indan;tert-Butyl((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate;(+/-)-trans-2-amino-1-{N-[(1,1-dimethylethoxy)]carbonylamino}indan

Chemical Property of tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property:

• PSA: 67.84000
• LogP: 3.04050
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 248.152477885
• Heavy Atom Count: 18
• Complexity: 311

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1C(CC2=CC=CC=C12)N
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@H]1[C@@H](CC2=CC=CC=C12)N

Technology Process of tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate

There total 5 articles about tert-Butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cis-1-[(1,1-dimethylethoxy)carbonylamino]-2-methanesulphonyloxyindan → tert-butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate (403860-48-0)

Guidance literature:

cis-1-[(1,1-dimethylethoxy)carbonylamino]-2-methanesulphonyloxyindan; With sodium azide; In ISOPROPYLAMIDE; at 90 ℃; for 6h;

With hydrogen; palladium 10% on activated carbon; In ISOPROPYLAMIDE; ethyl acetate; for 24h;

Reference yield: 98.0%

(1R,2R)-1-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-2-yl methanesulfonate (766556-67-6) → tert-butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate (403860-48-0)

Guidance literature:

(1R,2R)-1-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-2-yl methanesulfonate; With sodium azide; In N,N-dimethyl acetamide; at 90 ℃; for 3h;

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 4h;

Reference yield: 98.0%

tert-butyl N-[(1R,2S)-2-(methanesulfonyloxy)-2,3-dihydro-1H-inden-1-yl]carbamate (403860-49-1) → tert-butyl ((1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl)carbamate (403860-48-0)

Guidance literature:

tert-butyl N-[(1R,2S)-2-(methanesulfonyloxy)-2,3-dihydro-1H-inden-1-yl]carbamate; With sodium azide; In ISOPROPYLAMIDE; at 90 ℃; for 6h;

With hydrogen; palladium 10% on activated carbon; In ISOPROPYLAMIDE; ethyl acetate; for 24h;

upstream raw materials:

(1R,2R)-1-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-2-yl methanesulfonate

tert-butyl N-[(1R,2S)-2-(methanesulfonyloxy)-2,3-dihydro-1H-inden-1-yl]carbamate

(1R,2R)-trans-(2-azido-indan-1-yl)-carbamic acid tert-butyl ester

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