Technology Process of 1(2H)-Pyridinecarboxylic acid,
3-(benzoyloxy)-2-[(1S)-1,3-bis(acetyloxy)propyl]-3,6-dihydro-,
phenylmethyl ester, (2R,3S)-
There total 12 articles about 1(2H)-Pyridinecarboxylic acid,
3-(benzoyloxy)-2-[(1S)-1,3-bis(acetyloxy)propyl]-3,6-dihydro-,
phenylmethyl ester, (2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: 94 percent / NaBH4 / ethanol / 0.5 h / 20 °C
2.1: 94 percent / pyridine / 4.5 h / 0 °C
3.1: 96 percent / ethanol; H2O / 10 h / 20 °C
4.1: 99 percent / Et3N / CH2Cl2 / 3 h / 20 °C
5.1: DIBAL-H; (CH3)3COCH3 / toluene / 2.5 h / -78 °C
5.2: 974 mg / aq. AcOH / methanol / 0.5 h
6.1: 727 mg / NaBH4 / methanol / 0.33 h / 20 °C
7.1: 95 percent / DMAP; Et3N / CH2Cl2 / 1 h / 20 °C
8.1: 88 percent / m-CPBA / CH2Cl2 / 16 h / 20 °C
9.1: 94 percent / 4 Angstroem molecular sieves; BF3*Et2O / tetrahydrofuran / 3 h / 0 °C
10.1: 99 percent / CeCl3*7H2O; NaBH4 / methanol / 0.17 h / -78 °C
11.1: 92 percent / Ph3P; DEAD / tetrahydrofuran / 2 h / 20 °C
12.1: 88 percent / 88 percent formic acid; NaBH4 / 0.5 h / 0 °C
With
pyridine; dmap; sodium tetrahydroborate; formic acid; cerium(III) chloride; tert-butyl methyl ether; 4 A molecular sieve; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
11.1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)01258-9
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 727 mg / NaBH4 / methanol / 0.33 h / 20 °C
2: 95 percent / DMAP; Et3N / CH2Cl2 / 1 h / 20 °C
3: 88 percent / m-CPBA / CH2Cl2 / 16 h / 20 °C
4: 94 percent / 4 Angstroem molecular sieves; BF3*Et2O / tetrahydrofuran / 3 h / 0 °C
5: 99 percent / CeCl3*7H2O; NaBH4 / methanol / 0.17 h / -78 °C
6: 92 percent / Ph3P; DEAD / tetrahydrofuran / 2 h / 20 °C
7: 88 percent / 88 percent formic acid; NaBH4 / 0.5 h / 0 °C
With
dmap; sodium tetrahydroborate; formic acid; cerium(III) chloride; 4 A molecular sieve; boron trifluoride diethyl etherate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane;
6: Mitsunobu reaction;
DOI:10.1016/S0040-4020(02)01258-9
