2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl-

Base Information

Chemical Name:2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl-
CAS No.:403985-21-7
Molecular Formula:C38H41BrN2O8
Molecular Weight:733.656
Hs Code.:

2,4(1H,3H)-Pyrimidinedione,
1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl
methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl-

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl-

There total 4 articles about 2,4(1H,3H)-Pyrimidinedione, 1-[(2R,4S,5R)-4-(acetyloxy)-5-[(1S,3E)-1-[bis(4-methoxyphenyl)phenyl methoxy]-6-bromo-3-hexenyl]tetrahydro-2-furanyl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 403985-20-6
3'-O-acetoxy-5'-C-[(S)-5-bromopent-2-enyl]thymidine

: 403985-21-7
3'-O-acetoxy-5'-C-[(5'S)-5-bromopent-2-enyl]-5'-O-(dimethyloxytrityl)thymidine

Guidance literature:: With 2,3,5-trimethyl-pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃;
DOI:10.1002/1099-0690(200112)2001:24<4693::AID-EJOC4693>3.0.CO;2-J

Reference yield:

: 224177-29-1
5-<3'-(2''-bromoethyl)-4'-trimethylsilyl-2'-oxacyclopentyl>-4-t-butyldiphenylsilyloxy-2-thyminyl-1-oxacyclopentane

: 403985-21-7
3'-O-acetoxy-5'-C-[(5'S)-5-bromopent-2-enyl]-5'-O-(dimethyloxytrityl)thymidine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / HF*pyridine / tetrahydrofuran / 24 h

2: 95 percent / pyridine / CH₂Cl₂ / 20 h / 20 °C

3: 83 percent / titanium tetrachloride / CH₂Cl₂ / 0.25 h / 0 °C

4: 85 percent / collidine; silver nitrate / tetrahydrofuran / 20 °C

With pyridine; 2,3,5-trimethyl-pyridine; titanium tetrachloride; pyridine hydrogenfluoride; silver nitrate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/1099-0690(200112)2001:24<4693::AID-EJOC4693>3.0.CO;2-J

Reference yield:

: 403985-18-2
5-[(2'S)-5'-(2-bromoethyl)-4'-trimethysilyl-1'-oxacyclopent-2'-yl]-4-hydroxy-2-thyminyl-1-oxacyclopentane

: 403985-21-7
3'-O-acetoxy-5'-C-[(5'S)-5-bromopent-2-enyl]-5'-O-(dimethyloxytrityl)thymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / pyridine / CH₂Cl₂ / 20 h / 20 °C

2: 83 percent / titanium tetrachloride / CH₂Cl₂ / 0.25 h / 0 °C

3: 85 percent / collidine; silver nitrate / tetrahydrofuran / 20 °C

With pyridine; 2,3,5-trimethyl-pyridine; titanium tetrachloride; silver nitrate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/1099-0690(200112)2001:24<4693::AID-EJOC4693>3.0.CO;2-J