Acetamide, 2-bromo-N-[5-[6-[2-[[(2-nitrophenyl)sulfonyl]amino]ethyl]-2-pyridinyl]pent yl]-

Base Information

Chemical Name:Acetamide, 2-bromo-N-[5-[6-[2-[[(2-nitrophenyl)sulfonyl]amino]ethyl]-2-pyridinyl]pent yl]-
CAS No.:404034-82-8
Molecular Formula:C20H25BrN4O5S
Molecular Weight:513.412
Hs Code.:

Synonyms:

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Chemical Property of Acetamide, 2-bromo-N-[5-[6-[2-[[(2-nitrophenyl)sulfonyl]amino]ethyl]-2-pyridinyl]pent yl]-

Chemical Property:

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Technology Process of Acetamide, 2-bromo-N-[5-[6-[2-[[(2-nitrophenyl)sulfonyl]amino]ethyl]-2-pyridinyl]pent yl]-

There total 5 articles about Acetamide, 2-bromo-N-[5-[6-[2-[[(2-nitrophenyl)sulfonyl]amino]ethyl]-2-pyridinyl]pent yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 598-21-0
2-Bromoacetyl bromide

: 404034-83-9
N-{2-[6-(5-aminopentyl)pyridin-2-yl]ethyl}-2-nitrobenzenesulfonamide

: 404034-82-8
2-bromo-N-(5-{6-[2-(2-nitrobenzenesulfonylamino)ethyl]pyridin-2-yl}pentyl) acetamide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at -15 ℃; for 2h;
DOI:10.1021/jo0109523

Reference yield:

: 112575-11-8
2-(6-bromopyridin-2-yl)acetonitrile

: 404034-82-8
2-bromo-N-(5-{6-[2-(2-nitrobenzenesulfonylamino)ethyl]pyridin-2-yl}pentyl) acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: BF₃*THF / tetrahydrofuran / 18 h / 60 °C

2: 6.3 g / Et₃N / CH₂Cl₂ / 20 °C

3: (Ph₃P)2PdCl₂ / tetrahydrofuran

4: BH₃*Me₂S / tetrahydrofuran / 4 h / 60 °C

5: 311 mg / Na₂CO₃ / tetrahydrofuran / 2 h / -15 °C

With bis-triphenylphosphine-palladium(II) chloride; boron trifluoride-tetrahydrofuran complex; dimethylsulfide borane complex; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0109523

Reference yield:

: 404034-81-7
2-(6-bromopyridin-2-yl)ethylamine

: 404034-82-8
2-bromo-N-(5-{6-[2-(2-nitrobenzenesulfonylamino)ethyl]pyridin-2-yl}pentyl) acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 6.3 g / Et₃N / CH₂Cl₂ / 20 °C

2: (Ph₃P)2PdCl₂ / tetrahydrofuran

3: BH₃*Me₂S / tetrahydrofuran / 4 h / 60 °C

4: 311 mg / Na₂CO₃ / tetrahydrofuran / 2 h / -15 °C

With bis-triphenylphosphine-palladium(II) chloride; dimethylsulfide borane complex; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0109523