2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester

Base Information

Chemical Name:2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester
CAS No.:404597-65-5
Molecular Formula:C13H15NO6
Molecular Weight:281.265
Hs Code.:
DSSTox Substance ID:DTXSID901246230
Nikkaji Number:J1.618.383K
Mol file:404597-65-5.mol

Synonyms:DTXSID901246230;4-Ethyl 1-methyl 2-(2-nitrophenyl)butanedioate;2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester;404597-65-5

Suppliers and Price of 2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:281.08993720
Heavy Atom Count:20
Complexity:364

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(C1=CC=CC=C1[N+](=O)[O-])C(=O)OC

Technology Process of 2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester

There total 3 articles about 2-(2-Nitrophenyl)succinic acid 1-methyl 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 404597-64-4
2-methoxycarbonyl-2-(2-nitro-phenyl)-succinic acid 4-ethyl ester 1-methyl ester

: 404597-65-5
2-(2-nitro-phenyl)-succinic acid 4-ethyl ester 1-methyl ester

Guidance literature:: With sodium chloride; In dimethyl sulfoxide; at 110 ℃;
DOI:10.1016/S0040-4039(01)01809-3

Reference yield:

: 26465-37-2
dimethyl 2-(2-nitrophenyl)malonate

: 404597-65-5
2-(2-nitro-phenyl)-succinic acid 4-ethyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaH / tetrahydrofuran / 20 °C

2: 58 percent / NaCl / dimethylsulfoxide / 110 °C

With sodium hydride; sodium chloride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(01)01809-3

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 404597-65-5
2-(2-nitro-phenyl)-succinic acid 4-ethyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / NaH / tetrahydrofuran / 20 °C

2: 72 percent / NaH / tetrahydrofuran / 20 °C

3: 58 percent / NaCl / dimethylsulfoxide / 110 °C

With sodium hydride; sodium chloride; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(01)01809-3