Technology Process of 2,4-Pyrrolidinedicarboxylic acid,
2-methyl-4-[(S)-(4-methylphenyl)sulfinyl]-5-(2-naphthalenyl)-, dimethyl
ester, (2S,4R,5S)-
There total 4 articles about 2,4-Pyrrolidinedicarboxylic acid,
2-methyl-4-[(S)-(4-methylphenyl)sulfinyl]-5-(2-naphthalenyl)-, dimethyl
ester, (2S,4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
silver(I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
DOI:10.1021/jo010797s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LHMDS / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 87 percent / tetrahydrofuran / 3 h / -78 °C
2.1: acetonitrile; H2O / 48 h / 20 °C
3.1: methyl iodide; CaCO3 / acetonitrile / 1.5 h / 20 °C
4.1: 16 percent / AgOAc; DBU / tetrahydrofuran / 3 h / 0 °C
With
silver(I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; calcium carbonate; lithium hexamethyldisilazane; methyl iodide;
In
tetrahydrofuran; hexane; water; acetonitrile;
2.1: Mannich reaction;
DOI:10.1021/jo010797s
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetonitrile; H2O / 48 h / 20 °C
2: methyl iodide; CaCO3 / acetonitrile / 1.5 h / 20 °C
3: 16 percent / AgOAc; DBU / tetrahydrofuran / 3 h / 0 °C
With
silver(I) acetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; calcium carbonate; methyl iodide;
In
tetrahydrofuran; water; acetonitrile;
1: Mannich reaction;
DOI:10.1021/jo010797s