6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate

Base Information

• Chemical Name: 6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate
• CAS No.: 84371-31-3
• Molecular Formula: C₂₂H₂₆O₇
• Molecular Weight: 402.444
• Mol file: 84371-31-3.mol

Synonyms:6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate

Chemical Property of 6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate

Chemical Property:

• Vapor Pressure: 8.14E-18mmHg at 25°C
• Melting Point: 170 - 173 °C
• Boiling Point: 650.6°C at 760 mmHg
• Flash Point: 228.6°C
• PSA: 121.13000
• Density: 1.4g/cm³
• LogP: 2.69480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate

There total 9 articles about 6 alpha,16 alpha-dihydroxyestrone 6-hemisuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,16α-bis(tert-butyldimethylsilyloxy)-6α-hydroxy-1,3,5(10)-estratrien-17-one hemisuccinate → 3,6α,16α-trihydroxy-1,3,5(10)-estratrien-17-one 6-hemisuccinate (84371-31-3)

Guidance literature:

With hydrogenchloride; In acetone; Ambient temperature;

DOI:10.1016/0039-128X(82)90056-3

Reference yield:

3,16α-diacetoxy-1,3,5(10)-estratrien-17-one (1247-71-8) → 3,6α,16α-trihydroxy-1,3,5(10)-estratrien-17-one 6-hemisuccinate (84371-31-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 560 mg / CrO₃ / acetic acid; H₂O / 1) 4 deg C, 30 min, 2) r.t., overnight

2: 290 mg / BF₃-etherate / acetic acid / Ambient temperature

3: 1.4 g / HgCl₂, CaCO₃ / acetonitrile; H₂O / 0.5 h / Ambient temperature

4: 7 mg / 30percent KOH / methanol; dioxane / Ambient temperature

5: 300 mg / pyridine, imidazole / dimethylformamide / Ambient temperature

6: 245 mg / NaBH₄ / methanol / 0.08 h / 0 °C

7: 280 mg / HgCl₂, CaCO₃ / acetonitrile; H₂O / Heating

8: 108 mg / pyridine / 2.5 h / Heating

9: 14 mg / 1N HCl / acetone / Ambient temperature

With pyridine; 1H-imidazole; chromium(VI) oxide; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; calcium carbonate; mercury dichloride; In 1,4-dioxane; pyridine; methanol; water; acetic acid; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1016/0039-128X(82)90056-3

Reference yield:

3,16α-dihydroxy-1,3,5(10)-estratriene-6,17-dione 17-ethylenedithioketal → 3,6α,16α-trihydroxy-1,3,5(10)-estratrien-17-one 6-hemisuccinate (84371-31-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 300 mg / pyridine, imidazole / dimethylformamide / Ambient temperature

2: 245 mg / NaBH₄ / methanol / 0.08 h / 0 °C

3: 280 mg / HgCl₂, CaCO₃ / acetonitrile; H₂O / Heating

4: 108 mg / pyridine / 2.5 h / Heating

5: 14 mg / 1N HCl / acetone / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; calcium carbonate; mercury dichloride; In pyridine; methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1016/0039-128X(82)90056-3

upstream raw materials:

3,16α-diacetoxy-1,3,5(10)-estratrien-17-one

3,16α-diacetoxy-1,3,5(10)-estratriene-6,17-dione

3,16α-diacetoxy-1,3,5(10)-estratriene-6,17-dione 17-ethylenedithioketal

3,16α-bis(tert-butyldimethylsilyloxy)-6α-hydroxy-1,3,5(10)-estratrien-17-one

Refernces