1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one

Base Information

Chemical Name:1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one
CAS No.:405145-29-1
Molecular Formula:C12H16N2O
Molecular Weight:204.272
Hs Code.:
DSSTox Substance ID:DTXSID10573538
Nikkaji Number:J1.626.944A
Mol file:405145-29-1.mol

Synonyms:405145-29-1;1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one;DTXSID10573538

Suppliers and Price of 1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:204.126263138
Heavy Atom Count:15
Complexity:224

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)N2CCCNC2=O
Isomeric SMILES:C[C@H](C1=CC=CC=C1)N2CCCNC2=O

Technology Process of 1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one

There total 4 articles about 1-[(1R)-1-Phenylethyl]tetrahydropyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1-((R)-1-Phenyl-ethyl)-dihydro-pyrimidine-2,4-dione

: 405145-29-1
N-[(R)-1-phenylethyl]propyleneurea

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0040-4039(01)01875-5

Reference yield: 78.0%

: 159149-54-9
N-[(R)-1-phenylethyl]propylene-1,3-diamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 405145-29-1
N-[(R)-1-phenylethyl]propyleneurea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1002/poc.939

Reference yield:

: 159149-53-8
3-[(R)-1-phenylethylamino]propionitrile

: 405145-29-1
N-[(R)-1-phenylethyl]propyleneurea

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NH₃; H₂ / Rh(Al₂O₃) / methanol / 18 h / 20 °C / 25857.4 Torr

2: 78 percent / Et₃N / CH₂Cl₂ / 48 h / 20 °C

With ammonia; hydrogen; triethylamine; Rh/Al₂O₃; In methanol; dichloromethane;
DOI:10.1002/poc.939