4-Chloro-2-(chloromethyl)-3-methoxypyridine

Base Information

• Chemical Name: 4-Chloro-2-(chloromethyl)-3-methoxypyridine
• CAS No.: 409098-85-7
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.04300
• DSSTox Substance ID: DTXSID00473497
• Wikidata: Q82302930
• Mol file: 409098-85-7.mol

Synonyms:4-chloro-2-(chloromethyl)-3-methoxypyridine;409098-85-7;Pyridine, 4-chloro-2-(chloromethyl)-3-methoxy-;2-chloromethyl-3-methoxy-4-chloro-pyridine;SCHEMBL1178052;DTXSID00473497;KPQDKAMSAVONFC-UHFFFAOYSA-N;4-Chloro-3-methoxy-2-chloromethyl pyridine hydrochloride

Chemical Property of 4-Chloro-2-(chloromethyl)-3-methoxypyridine

Chemical Property:

• Boiling Point: 249.8±35.0 °C(Predicted)
• PKA: 2.05±0.10(Predicted)
• PSA: 22.12000
• Density: 1.312±0.06 g/cm3(Predicted)
• LogP: 2.48240
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.9904692
• Heavy Atom Count: 11
• Complexity: 123

Purity/Quality:

99.0% ^*data from raw suppliers

4-CHLORO-2-(CHLOROMETHYL)-3-METHOXYPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CN=C1CCl)Cl

Technology Process of 4-Chloro-2-(chloromethyl)-3-methoxypyridine

There total 1 articles about 4-Chloro-2-(chloromethyl)-3-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxymethyl-3-methoxy-4-chloro-pyridine hydrochloride (848676-41-5) → 4-chloro-2-(chloromethyl)-3-methoxypyridine (409098-85-7)

Guidance literature:

With thionyl chloride; In toluene; at 15 - 25 ℃; for 1h;

Reference yield: 82.8%

4-chloro-2-(chloromethyl)-3-methoxypyridine (409098-85-7) + 5-(difluoromethoxy)-2-mercapto-1H-benzimidazole (97963-62-7) → (5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole (368890-20-4)

Guidance literature:

4-chloro-2-(chloromethyl)-3-methoxypyridine; With sodium methylate; In methanol; toluene; at 15 - 25 ℃; for 1h;

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole; In methanol; toluene; for 0.5h;

With sodium methylate; In methanol; toluene; at 15 - 35 ℃; for 1h;

upstream raw materials:

2-hydroxymethyl-3-methoxy-4-chloro-pyridine hydrochloride

Downstream raw materials:

(5-difluoromethoxy)-2-[(4-chloro-3-methoxy-2-pyridinyl)methyl]thio-1H-benzimidazole