3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol

Base Information

• Chemical Name: 3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol
• CAS No.: 41009-85-2
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• European Community (EC) Number: 873-443-8
• ChEMBL ID: CHEMBL4549363
• Nikkaji Number: J803.781G
• Mol file: 41009-85-2.mol

Synonyms:3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol;41009-85-2;3,3'-(1,3-Phenylene)bis(propan-1-ol);SCHEMBL241880;CHEMBL4549363;1,3-bis(3-hydroxypropyl)benzene;OTILCBBQTIFAGJ-UHFFFAOYSA-N;AKOS006312553;EN300-208174;G53353;Z1198265451

Chemical Property of 3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 194.130679813
• Heavy Atom Count: 14
• Complexity: 122

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)CCCO)CCCO

Technology Process of 3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol

There total 14 articles about 3-[3-(3-Hydroxypropyl)phenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,3′-(1,3-phenylene)dipropionic acid (6082-86-6) → 3-(3-(3-hydroxypropyl)phenyl)propanol (41009-85-2)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 70 ℃; for 6h;

Reference yield: 81.0%

3,3'-(1,3-phenylene)bis(ethyl propionate) (143260-96-2) → 3-(3-(3-hydroxypropyl)phenyl)propanol (41009-85-2)

Guidance literature:

3,3'-(1,3-phenylene)bis(ethyl propionate); With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 79.0%

3-[3-(2-ethoxycarbonylvinyl)phenyl]acrylic acid ethyl ester (30853-80-6) → 3-(3-(3-hydroxypropyl)phenyl)propanol (41009-85-2)

Guidance literature:

3-[3-(2-ethoxycarbonylvinyl)phenyl]acrylic acid ethyl ester; With hydrogen; palladium on activated charcoal; In methanol;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2005.11.107

upstream raw materials:

3,3'-m-phenylene-di-propionic acid dimethyl ester

3,3'-(1,3-phenylene)bis(ethyl propionate)

3,3′-(1,3-phenylene)dipropionic acid

3-[3-(2-ethoxycarbonylvinyl)phenyl]acrylic acid ethyl ester

Downstream raw materials:

1,3-bis(3-bromopropyl)benzene

Acetic acid 3-[3-(3-hydroxy-propyl)-phenyl]-propyl ester

m-Benzoldibutannitril

4,4'-(benzene-1,3-diyl)dibutanoic acid