3-IODOCINNAMIC ACID

Base Information

• Chemical Name: 3-IODOCINNAMIC ACID
• CAS No.: 41070-12-6
• Molecular Formula: C9H7IO2
• Molecular Weight: 274.058
• Hs Code.: 2916399090
• Mol file: 41070-12-6.mol

Synonyms:3-methyliodobenzene;3-Jod-trans-zimtsaeure;3-iodo-trans-cinnamic acid;3-Jod-zimtsaeure;3-iodo-toluene;Toluene,m-iodo-(7CI,8CI);Toluene,m-iodo;3-Methylphenyl iodide;Benzene,1-iodo-3-methyl;m-iodotoluene;trans m-iodocinnamic acid;m-Tolyl iodide;3-Me-C6H4-I;m-Methyliodobenzene;3-iodocinnamic acid;

Chemical Property of 3-IODOCINNAMIC ACID

Chemical Property:

• PSA: 37.30000
• LogP: 2.38900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

3-(3-Iodophenyl)acrylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-IODOCINNAMIC ACID

There total 4 articles about 3-IODOCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-Bromocinnamic acid (14473-91-7) → 3-iodocinnamic acid (41070-12-6)

Guidance literature:

With trans-N,N'-dimethylcyclohexane-1,2-diamine; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 22h;

Reference yield:

3-iodocinnamic acid trimethylsilyl ester → 3-iodocinnamic acid (41070-12-6)

Guidance literature:

With hydrogenchloride; sodium metabisulfite; In 1,4-dioxane; diethyl ether; at 20 ℃;

DOI:10.1021/ja028865v

Reference yield:

m-iodobenzaldehyde (696-41-3) + acetic anhydride (108-24-7) → 3-iodocinnamic acid (41070-12-6)

Guidance literature:

With sodium acetate;

upstream raw materials:

m-aminocinnamic acid

m-iodobenzaldehyde

acetic anhydride

3-Bromocinnamic acid

Downstream raw materials:

3-hydroxy-trans-cinnamic acid

3-iodo-N-ethylcinnamamide

3-(3-iodophenyl)propanoic acid

(E)-ethyl 3-(3-iodophenyl)acrylate

Refernces

• 1、 Klapars, Artis,Buchwald, Stephen L.. "Copper-catalyzed halogen exchange in aryl halides: An aromatic finkelstein reaction". . p. 14844 - 14845. Retrieved 2007/10/03.