10.1007/s10593-020-02632-5
The research focuses on the development of an efficient, environmentally friendly method for synthesizing 1,2,4-thiadiazole derivatives, which are important heterocyclic compounds with a range of biological activities and therapeutic applications. The study introduces a metal- and catalyst-free protocol that utilizes the combination of water and ultrasound technique to achieve the dimerization of primary thioamide derivatives with chloranil, leading to the formation of 1,2,4-thiadiazoles. The optimized reaction conditions resulted in excellent yields within a short reaction time, demonstrating a significant improvement over traditional methods. The chemicals used in the process include primary thioamide derivatives, chloranil as the oxidizing agent, and water as the solvent, with other solvents like MeCN, THF, EtOH, 1,4-dioxane, CHCl3, CH2Cl2, DCE, and DMSO also tested for comparison. The study concludes that the ultrasound-initiated green synthesis in water is a valuable addition to existing methods for synthesizing substituted 3,5-diaryl-1,2,4-thiadiazoles, offering a rapid and efficient approach.